ArticlePulmonary circulation2013
Time from symptoms to definitive diagnosis of idiopathic pulmonary arterial hypertension: The delay study.
Article in Pulmonary circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 141 citations in OpenAlex.
- Diagnostic performance of artificial intelligence-enabled electrocardiography for pulmonary hypertension: a systematic review and meta-analysis.European heart journal. Digital health · 2026Review
- Referral Patterns and Clinical Characteristics of Patients With Pulmonary Hypertension at a Comprehensive Care Center.Pulmonary circulation · 2026Article
- The impact of right ventricular free wall strain on current international echocardiography guidelines for the assessment of pulmonary hypertension.Echo research and practice · 2026Article
- Conceptual Reconsideration of the Classification of Pulmonary Hypertension: From 5 Groups to 2 Groups.JACC. Asia · 2026Review
- Treatment of Pulmonary Arterial Hypertension in Lithuania: Current Situation and Analysis of Survival of Patients Treated with Different Treatment Regimens.Journal of clinical medicine · 2026Article
- Challenges and opportunities in assessing right ventricular structure and function: a Roadmap for standardization, clinical implementation and research.Nature reviews. Cardiology · 2026Review
- Time to Therapy Activation and Initial Combination Therapy (TITANIC) for Patients With Pulmonary Arterial Hypertension.Pulmonary circulation · 2026Article
- Assessing the Impact of Time to Diagnosis and Treatment for Patients With Pulmonary Arterial Hypertension.Pulmonary circulation · 2025Article
- Clinical validation of a machine-learned, point-of-care system to IDENTIFY pulmonary hypertension.ERJ open research · 2025Article
- Gaps in access to pulmonary hypertension care and opportunities for improvement: a multi-site qualitative study.BMC pulmonary medicine · 2025Article
- Location of Terminal Care in Pulmonary Hypertension.CJC open · 2025Article
- Factors Associated with Referral to Expert Providers among Patients with Pulmonary Hypertension.Annals of the American Thoracic Society · 2025Article
- Left Main Coronary Artery Angioplasty for the Treatment of Extrinsic Compression in Patients with Pulmonary Hypertension.Arquivos brasileiros de cardiologia · 2025Article
- An ensemble learning model for detection of pulmonary hypertension using electrocardiogram, chest X-ray, and brain natriuretic peptide.European heart journal. Digital health · 2025Article
- Managing Symptoms of Systemic Sclerosis for the Allergist-Immunologist.Current allergy and asthma reports · 2024Review
- An electrocardiogram-based AI algorithm for early detection of pulmonary hypertension.The European respiratory journal · 2024Article
- Early detection of pulmonary arterial hypertension through [Pulmonary circulation · 2024Article
- Two prospective, multicenter studies for the identification of biomarker signatures for early detection of pulmonary hypertension (PH): The CIPHER and CIPHER-MRI studies.Pulmonary circulation · 2024Article
- Artificial intelligence-based model for predicting pulmonary arterial hypertension on chest x-ray images.BMC pulmonary medicine · 2024Article
- 'Fear, uncertain, tired…...' psychological distress among pulmonary hypertension patients: a qualitative interview study.BMC psychiatry · 2024Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Survival rates for patients with idiopathic pulmonary arterial hypertension (IPAH) have improved with the introduction of PAH-specific therapies. However, the time between patient-reported onset of symptoms and a definitive diagnosis of IPAH is consistently delayed. We conducted a retrospective, multi-center, descriptive investigation in order to (a) understand what factors contribute to persistent diagnostic delays, and (b) examine the time from initial symptom onset to a definitive diagnosis of IPAH. Between January 2007 and December 2008, we enrolled consecutively diagnosed adults with IPAH from four tertiary referral centers in Australia. Screening of patient records and "one-on-one" interviews were used to determine the time from patient-described initial symptoms to a diagnosis of IPAH, confirmed by right heart catheterization (RHC). Thirty-two participants (69% female) were studied. Mean age at symptom onset was 56 ± 16.4 years and 96% reported exertional dyspnea. Mean time from symptom onset to diagnosis was 47 ± 34 months with patients subsequently aged 60 ± 17.3 years. Patients reported 5.3 ± 3.8 GP visits and 3.0 ± 2.1 specialist reviews before being seen at a pulmonary hypertension (PH) center. Advanced age, number of general practitioner (GP) visits, heart rate, and systolic blood pressure at the time of diagnosis were significantly associated with the observed delay. We found a significant delay of 3.9 years from symptom onset to a diagnosis of IPAH in Australia. Exertional dyspnea is the most common presenting symptom. Current practice within Australia does not appear to have the specific capacity for timely, multi-factorial evaluation of breathlessness and potential IPAH.
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