ArticleEvidence-based complementary and alternative medicine : eCAM2013
Platelet aggregation pathway network-based approach for evaluating compounds efficacy.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Integrating Network Pharmacology, Quantitative Metabolic Network Analysis,Combinatorial chemistry & high throughput screening · 2025Article
- Uses of Molecular Docking Simulations in Elucidating Synergistic, Additive, and/or Multi-Target (SAM) Effects of Herbal Medicines.Molecules (Basel, Switzerland) · 2024Review
- Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Herb-target interaction network analysis helps to disclose molecular mechanism of traditional Chinese medicine.Scientific reports · 2016Article
- Quantitative modeling of dose-response and drug combination based on pathway network.Journal of cheminformatics · 2015Article
- An Integrative Thrombosis Network: Visualization and Topological Analysis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology.Journal of cheminformatics · 2013Article
- A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional Chinese medicines (TCMs) contain a large quantity of compounds with multiple biological activities. By using multitargets docking and network analysis in the context of pathway network of platelet aggregation, we proposed network efficiency and network flux model to screen molecules which can be used as drugs for antiplatelet aggregation. Compared with traditional single-target screening methods, network efficiency and network flux take into account the influences which compounds exert on the whole pathway network. The activities of antiplatelet aggregation of 19 active ingredients separated from TCM and 14 nonglycoside compounds predicated from network efficiency and network flux model show good agreement with experimental results (correlation coefficient = 0.73 and 0.90, resp.). This model can be used to evaluate the potential bioactive compounds and thus bridges the gap between computation and clinical indicator.
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Registered trials
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