ArticleThe British journal of psychiatry : the journal of mental science2013
Changes in capacity to consent over time in patients involved in psychiatric research.
Article in The British journal of psychiatry : the journal of mental science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Capacity to Consent in Healthcare: A Systematic Review and Meta-Analysis Comparing Patients with Bipolar Disorders and Schizophrenia Spectrum Disorders.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Consent for Research Involving Spanish- and English-Speaking Latinx Adults With Schizophrenia.Schizophrenia bulletin · 2024Trial
- Consenting practices to enhance comprehension in research involving individuals with schizophrenia and bipolar affective disorder in Uganda: a qualitative inquiry.BMC psychology · 2026Article
- Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026Review
- Research assistants' experiences recruiting patients with psychosis into clinical trials: a qualitative study.Trials · 2025Article
- Fitness to plead: Development and validation of a standardised assessment instrument.PloS one · 2018Article
- Mental Capacity Assessments Among Inpatients Referred to the Consultation-Liaison Psychiatry Unit at a University Hospital in Bangkok, Thailand.The Psychiatric quarterly · 2017Article
- Functional mental capacity, treatment as usual and time: magnitude of change in secure hospital patients with major mental illness.BMC research notes · 2015Article
- Ethics in Psychiatric Research: Issues and Recommendations.Indian journal of psychological medicineReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundInformed consent is a key element of ethical clinical research. Patients with serious mental illness may be at risk for impaired consent capacity. Corrective feedback improves within-session comprehension of consent-relevant information, but little is known about the trajectory of patients' comprehension after the initial enrolment session.
aimsTo examine whether within-session gains in understanding after feedback were maintained between study visits and to examine stability of decisional capacity over time.
methodThis was a longitudinal, within-participants comparison of decisional capacity assessed at baseline, 1 week, 3 months, 12 months and 24 months in 161 people with schizophrenia or bipolar disorder.
resultsWithin-session gains from corrective feedback generally dissipated over each follow-up interval. Decisional capacity showed a general pattern of stability, but there was significant between-participant heterogeneity. Better neuropsychological performance was associated with better decisional capacity across time points. Positive symptoms of schizophrenia did not predict any aspects of decisional capacity, but general psychopathology, negative symptoms and depression evidenced some modest associations with certain subdomains of decisional capacity.
conclusionsInformed consent may be most effectively construed as an ongoing dialogue with participants at each study visit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.