ArticleArteriosclerosis, thrombosis, and vascular biology2013
Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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42 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- A case of simultaneous adrenalectomy and dissection repair with direct sheath placement into the aorta and systematic review of cases with hyperaldosteronism and vascular dissection: a case report.Journal of medical case reports · 2025Pooled it
- Reported high salt intake is associated with increased prevalence of abdominal aortic aneurysm and larger aortic diameter in older men.PloS one · 2014Trial
- Animal Models of Aortic Aneurysm and Dissection: A Comparative Guide for Mechanism, Therapeutic Testing, and Translational Readouts.Biomedicines · 2026Review
- Calcium channel blockers increase the risk of aortic aneurysm and dissection.Nature communications · 2025Article
- Review
- Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Aldosterone-Induced Transformation of Vascular Smooth Muscle Cells into Macrophage-like Cells Participates in Inflammatory Vascular Lesions.International journal of molecular sciences · 2025Article
- Global burden of aortic aneurysm attributable to high-sodium diet from 1990 to 2021.Frontiers in nutrition · 2025Article
- Unleashing PD-1: a duel of immunity in aortic aneurysm formation.The Journal of clinical investigation · 2024Article
- Androgen aggravates aortic aneurysms via suppression of PD-1 in mice.The Journal of clinical investigation · 2024Article
- Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Higher plasma aldosterone concentrations in patients with aortic diseases and hypertension: a retrospective observational study.European journal of medical research · 2023Observational
- A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population.Journal of atherosclerosis and thrombosis · 2023Article
- The mechanism and therapy of aortic aneurysms.Signal transduction and targeted therapy · 2023Review
- Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing.Cardiovascular research · 2023Article
- Molecular and Cellular Mechanisms Involved in Aortic Wall Aneurysm Development.Diagnostics (Basel, Switzerland) · 2023Review
- Development of pharmacotherapies for abdominal aortic aneurysms.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Fludrocortisone Induces Aortic Pathologies in Mice.Biomolecules · 2022Article
- Aldosterone and Aortic Aneurysms: the Dissection of a Potential New Mechanism to Prevent Rupture.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Twenty Years of Studying AngII (Angiotensin II)-Induced Abdominal Aortic Pathologies in Mice: Continuing Questions and Challenges to Provide Insight Into the Human Disease.Arteriosclerosis, thrombosis, and vascular biology · 2022Review
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7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveElevated plasma aldosterone concentrations in patients have been linked to a spectrum of cardiovascular diseases. Mineralocorticoid receptor antagonists provide additional benefits in patients with heart failure. However, whether aldosterone and the mineralocorticoid receptor are involved in aortic aneurysm is unknown. APPROACH AND
resultsWe report that administration of deoxycorticosterone acetate (DOCA) and salt or aldosterone and salt, but not DOCA or salt alone, to C57BL/6 male mice induced abdominal and thoracic aortic aneurysm formation and rupture in an age-dependent manner. DOCA and salt- or aldosterone and salt-induced aortic aneurysm mimicked human aortic aneurysm with respect to elastin degradation, inflammatory cell infiltration, smooth muscle cell degeneration and apoptosis, and oxidative stress. Aortic aneurysm formation did not correlate with the increase in blood pressure induced by DOCA and salt. Systemic administration of the angiotensin-converting enzyme inhibitor, enalapril, or angiotensin type 1 receptor antagonist, losartan, did not affect DOCA and salt-induced aortic aneurysm. In contrast, the mineralocorticoid receptor antagonists, spironolactone or eplerenone, significantly attenuated DOCA and salt- or aldosterone and salt-induced aortic aneurysm.
conclusionsThe current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm. These findings imply that mineralocorticoid receptor antagonists may be effective in the treatment of some aortic aneurysms.
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