Trial reportSchizophrenia bulletin2014
Dopaminergic modulation of probabilistic reasoning and overconfidence in errors: a double-blind study.
Trial report in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- Dopaminergic Drugs Modulate Resting-State EEG Microstates in Healthy Participants.Brain topography · 2026Trial
- Potential Delayed Positive Effects of tDCS on Improving Introspective Accuracy in Social Cognition in Schizophrenia.Schizophrenia bulletin · 2025Trial
- Confidence in visual motion discrimination is preserved in individuals with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2021Trial
- Beta-Blocker Propranolol Modulates Decision Urgency During Sequential Information Gathering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Trial
- Dopamine effects on evidence gathering and integration.Journal of psychiatry & neuroscience : JPN · 2015Trial
- Associations of conservatism and jumping to conclusions biases with aberrant salience and default mode network.Psychiatry and clinical neurosciences · 2024Article
- Metacognitive training for psychosis (MCT): past, present, and future.European archives of psychiatry and clinical neuroscience · 2023Review
- Can you trust this source? Advice taking in borderline personality disorder.European archives of psychiatry and clinical neuroscience · 2023Article
- Neurocognitive bases of self-monitoring of inner speech in hallucination prone individuals.Scientific reports · 2023Article
- Rethinking delusions: A selective review of delusion research through a computational lens.Schizophrenia research · 2022Review
- Rational inattention and tonic dopamine.PLoS computational biology · 2021Article
- Overestimation of volatility in schizophrenia and autism? A comparative study using a probabilistic reasoning task.PloS one · 2021Article
- Dopamine manipulations drive changes in information sampling in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2019Article
- Cost Evaluation During Decision-Making in Patients at Early Stages of Psychosis.Computational psychiatry (Cambridge, Mass.) · 2019Article
- Dopamine is a double-edged sword: dopaminergic modulation enhances memory retrieval performance but impairs metacognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Attractor-like Dynamics in Belief Updating in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training.NeuroImage. Clinical · 2018Observational
- Increased decision thresholds enhance information gathering performance in juvenile Obsessive-Compulsive Disorder (OCD).PLoS computational biology · 2017Article
- The new frontier in health services research: a behavioural paradigm guided by genetics.Journal of health services research & policy · 2017Article
- Neural Habituation to Painful Stimuli Is Modulated by Dopamine: Evidence from a Pharmacological fMRI Study.Frontiers in human neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionReasoning biases such as jumping to conclusions (JTC) and overconfidence in errors have been well replicated in patients with delusions. However, their relation to dopaminergic activity, central to pathophysiologic models of psychosis, has not yet been investigated. This study aimed to examine the effects of a dopaminergic agonist (L-dopa) and a dopaminergic antagonist (haloperidol) on the JTC bias and overconfidence in errors after single-dose administration in healthy individuals.
methodsThe study used a randomized, double-blind, placebo-controlled, 3-way crossover design. Participants were 36 healthy individuals aged 18-36 years. The variables of interest were draws to decision and probability threshold to decision on a computerized variant of the beads task and the number of high-confident incorrect responses on a visual memory task.
resultsThere were no significant effects of substance on draws to decision and probability threshold to decision. A significant effect emerged for high-confident incorrect responses in the memory task; pairwise comparisons indicated a significant reduction of the number of high-confident incorrect responses after administration of haloperidol vs l-dopa and placebo.
conclusionsThis is the first study to investigate the direct effects of dopaminergic drugs on reasoning biases. The JTC bias and overconfidence in errors showed a differential pattern of dopaminergic modulation, suggesting that they represent different facets of reasoning abnormalities that interact with each other to produce delusions in susceptible individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.