ArticleSchizophrenia bulletin2014
Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Deviations from normative brain white and gray matter structure are associated with psychopathology in youth.Developmental cognitive neuroscience · 2022Article
- Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network.Nature communications · 2022Article
- Recognition of the Multi-class Schizophrenia Based on the Resting-State EEG Network Topology.Brain topography · 2022Article
- Effects of Brain Atlases and Machine Learning Methods on the Discrimination of Schizophrenia Patients: A Multimodal MRI Study.Frontiers in neuroscience · 2021Article
- Quantitative Macromolecular Proton Fraction Mapping Reveals Altered Cortical Myelin Profile in Schizophrenia Spectrum Disorders.Cerebral cortex communications · 2021Article
- Microstructural White Matter and Links With Subcortical Structures in Chronic Schizophrenia: A Free-Water Imaging Approach.Frontiers in psychiatry · 2020Article
- Linking Cortical and Connectional Pathology in Schizophrenia.Schizophrenia bulletin · 2019Article
- Measuring the Non-linear Directed Information Flow in Schizophrenia by Multivariate Transfer Entropy.Frontiers in computational neuroscience · 2019Article
- Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion.Nature communications · 2018Article
- Multimodal Fusion With Reference: Searching for Joint Neuromarkers of Working Memory Deficits in Schizophrenia.IEEE transactions on medical imaging · 2018Article
- SchizConnect: Mediating neuroimaging databases on schizophrenia and related disorders for large-scale integration.NeuroImage · 2016Article
- Longitudinal Changes in White Matter Tract Integrity across the Adult Lifespan and Its Relation to Cortical Thinning.PloS one · 2016Article
- Characterization of the Fiber Connectivity Profile of the Cerebral Cortex in Schizotypal Personality Disorder: A Pilot Study.Frontiers in psychology · 2016Article
- Article
- Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- Synchronous Changes of Cortical Thickness and Corresponding White Matter Microstructure During Brain Development Accessed by Diffusion MRI Tractography from Parcellated Cortex.Frontiers in neuroanatomy · 2015Article
- Methods for identifying subject-specific abnormalities in neuroimaging data.Human brain mapping · 2014Article
- Association of GRM3 polymorphism with white matter integrity in schizophrenia.Schizophrenia research · 2014Article
- A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology.Diagnostic and interventional radiology (Ankara, Turkey)Article
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9 authors.
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Abstract
Typical brain development includes coordinated changes in both white matter (WM) integrity and cortical thickness (CT). These processes have been shown to be disrupted in schizophrenia, which is characterized by abnormalities in WM microstructure and by reduced CT. The aim of this study was to identify patterns of association between WM markers and cortex-wide CT in healthy controls (HCs) and patients with schizophrenia (SCZ). Using diffusion tensor imaging and structural magnetic resonance imaging data of the Mind Clinical Imaging Consortium study (130 HC and 111 SCZ), we tested for associations between (a) fractional anisotropy in selected manually labeled WM pathways (corpus callosum, anterior thalamic radiation, and superior longitudinal fasciculus) and CT, and (b) the number of lesion-like WM regions ("potholes") and CT. In HC, but not SCZ, we found highly significant negative associations between WM integrity and CT in several pathways, including frontal, temporal, and occipital brain regions. Conversely, in SCZ the number of WM potholes correlated with reduced CT in the left lateral temporal gyrus, left fusiform, and left lateral occipital brain area. Taken together, we found differential patterns of association between WM integrity and CT in HC and SCZ. Although the pattern in HC can be explained from a developmental perspective, the reduced gray matter CT in SCZ patients might be the result of focal but spatially heterogeneous disruptions of WM integrity.
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