ArticleGenome biology and evolution2013
Cytoplasmic organelle DNA preferentially inserts into open chromatin.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Review
- Continuous infiltration and evolutionary trajectory of nuclear organelle DNA inGenome research · 2025Article
- Suppression of plastid-to-nucleus gene transfer by DNA double-strand break repair.Nature plants · 2025Article
- Evolutionary dynamics of mitochondrial genomes and intracellular transfers among diploid and allopolyploid cotton species.BMC biology · 2025Article
- Evolutionary trajectory of organelle-derived nuclear DNAs in the Triticum/Aegilops complex species.Plant physiology · 2024Article
- Article
- Article
- A Chromosome-Level Genome Assembly of the European Beech (Frontiers in genetics · 2021Article
- Whole-genome de novo assemblies reveal extensive structural variations and dynamic organelle-to-nucleus DNA transfers in African and Asian rice.The Plant journal : for cell and molecular biology · 2020Article
- Doxorubicin-Induced Translocation of mtDNA into the Nuclear Genome of Human Lymphocytes Detected Using a Molecular-Cytogenetic Approach.International journal of molecular sciences · 2020Article
- Nuclear Integrants of Organellar DNA Contribute to Genome Structure and Evolution in Plants.International journal of molecular sciences · 2020Review
- The Transfer of the Ferredoxin Gene From the Chloroplast to the Nuclear Genome Is Ancient Within the Paraphyletic GenusFrontiers in microbiology · 2020Article
- Intergenomic gene transfer in diploid and allopolyploid Gossypium.BMC plant biology · 2019Article
- Mosaic mitochondrial-plastid insertions into the nuclear genome show evidence of both non-homologous end joining and homologous recombination.BMC evolutionary biology · 2018Article
- Single molecule mtDNA fiber FISH for analyzing numtogenesis.Analytical biochemistry · 2018Article
- The Roles of Mitochondrion in Intergenomic Gene Transfer in Plants: A Source and a Pool.International journal of molecular sciences · 2018Article
- Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.Seminars in cancer biology · 2017Review
- Mitochondrial determinants of cancer health disparities.Seminars in cancer biology · 2017Review
- Intercompartmental Piecewise Gene Transfer.Genes · 2017Review
- Transposable elements (TEs) contribute to stress-related long intergenic noncoding RNAs in plants.The Plant journal : for cell and molecular biology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA transfer from chloroplasts and mitochondria to the nucleus is ongoing in eukaryotes but the mechanisms involved are poorly understood. Mitochondrial DNA was observed to integrate into the nuclear genome through DNA double-strand break repair in Nicotiana tabacum. Here, 14 nuclear insertions of chloroplast DNA (nupts) that are unique to Oryza sativa subsp. indica were identified. Comparisons with the preinsertion nuclear loci identified in the related subspecies, O. sativa subsp. japonica, which lacked these nupts, indicated that chloroplast DNA had integrated by nonhomologous end joining. Analyzing public DNase-seq data revealed that nupts were significantly more frequent in open chromatin regions of the nucleus. This preference was tested further in the chimpanzee genome by comparing nuclear loci containing integrants of mitochondrial DNA (numts) with their corresponding numt-lacking preinsertion sites in the human genome. Mitochondrial DNAs also tended to insert more frequently into regions of open chromatin revealed by human DNase-seq and Formaldehyde-Assisted Isolation of Regulatory Elements-seq databases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.