ArticleEuropean journal of pediatrics2014
The burden of seasonal and pandemic influenza in infants and children.
Article in European journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Economic evaluation of pediatric influenza immunization program compared with other pediatric immunization programs: A systematic review.Human vaccines & immunotherapeutics · 2016Pooled it
- Trial
- Bioavailability of a novel anti-influenza agent, onradivir granules, in healthy Chinese adults: a first-in-human study.Frontiers in pharmacology · 2026Trial
- Impact of multifaceted health education on influenza vaccination health literacy in primary school students: a cluster randomized controlled trial.BMC medicine · 2025Trial
- Pediatric practice experiences with second dose influenza vaccination: An AAP Pediatric Research in Office Settings (PROS) Study.Public health · 2024Trial
- Effect of maternal vaccination on infant morbidity in Bangladesh.BMC public health · 2024Trial
- RDN for the treatment of influenza in children: a randomized, double-blinded, parallel-controlled clinical trial.BMC complementary medicine and therapies · 2023Trial
- Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children: A Randomized, Double-blind, Active Controlled Phase 3 Safety and Efficacy Trial (miniSTONE-2).The Pediatric infectious disease journal · 2020Trial
- Immunogenicity and safety of a quadrivalent inactivated influenza vaccine in pregnant women: a randomized, observer-blind trial.Human vaccines & immunotherapeutics · 2020Trial
- Anamnestic Immune Response and Safety of an Inactivated Quadrivalent Influenza Vaccine in Primed Versus Vaccine-Naïve Children.The Pediatric infectious disease journal · 2019Trial
- MF59-adjuvanted influenza vaccine (FLUAD®) elicits higher immune responses than a non-adjuvanted influenza vaccine (Fluzone®): A randomized, multicenter, Phase III pediatric trial in Mexico.Human vaccines & immunotherapeutics · 2018Trial
- Heterogeneous shedding of influenza by human subjects and its implications for epidemiology and control.Scientific reports · 2016Trial
- Systems-level insights into age-dependent innate immune responses in influenza B infection.Microbiology spectrum · 2026Article
- Role of Chinese Medicine in Treating Pediatric Respiratory Infections: A Comprehensive Review.Chinese journal of integrative medicine · 2026Review
- Acute viral infection accelerates neurodegeneration in a mouse model of ALS.Nature communications · 2026Article
- Genomic insights into influenza A(H1N1)pdm09 virus evolution in Yunnan province, China, during 2018-2023.Virology journal · 2026Article
- Influenza Antiviral Prescriptions in the US Inpatient and Outpatient Settings During the 2015-2022 Influenza Seasons.Influenza and other respiratory viruses · 2026Article
- Population Pharmacokinetic and Exposure-Efficacy Analysis of Baloxavir Marboxil for Influenza Treatment and Post-Exposure Prophylaxis in Children.Clinical pharmacology and therapeutics · 2026Article
- Hospitalized children with influenza virus: a 17 year-long observational study including the 2009 H1N1 influenza pandemic and COVID-19 pandemic.BMC infectious diseases · 2026Observational
- Impact of demographic, clinical, and viral factors on severe influenza in young children in Fuzhou.Frontiers in public health · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe burden of influenza is unevenly distributed, with more severe outcomes in children aged <5 years than older children and adults. In spite of this, immunisation policies for young children are far from universal. This article provides an overview of the published evidence on the burden of influenza in children worldwide, with a particular interest in the impact of pandemic influenza in 2009-2010 (caused by the H1N1pdm09 virus). In an average season, up to 9.8 % of 0- to 14-year olds present with influenza, but incidence rates can be markedly higher in younger children. Children aged <5 years have greater rates of hospitalisation and complications than their older counterparts, particularly if the children have co-existing illnesses; historically, this age group have had higher mortality rates from the disease than other children, although during the 2009-2010 pandemic the median age of those who died of influenza was higher than in previous seasons. Admissions to hospital and emergency departments appear to have been more frequent in children with H1N1pdm09 infections than during previous seasonal epidemics, with pneumonia continuing to be a common complication in this setting. Outcomes in children hospitalised with severe disease also seem to have been worse for those infected with H1N1pdm09 viruses compared with seasonal viruses. Studies in children confirm that vaccination reduces the incidence of seasonal influenza and the associated burden, underlining the importance of targeting this group in national immunisation policies.
conclusionsChildren aged <5 years are especially vulnerable to influenza, particularly that caused by seasonal viruses, and vaccination in this group can be an effective strategy for reducing disease burden.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.