ArticleJournal of computational neuroscience2013
Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments.
Article in Journal of computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 97 citations in OpenAlex.
- Setting a double-capacitive neuron coupled with Josephson junction and piezoelectric source.Cognitive neurodynamics · 2024Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Parameter Inference for an Astrocyte Model using Machine Learning Approaches.bioRxiv : the preprint server for biology · 2023Article
- Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes.Entropy (Basel, Switzerland) · 2023Article
- Connectome-based biophysics models of Alzheimer's disease diagnosis and prognosis.Translational research : the journal of laboratory and clinical medicine · 2023Review
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- The computational power of the human brain.Frontiers in cellular neuroscience · 2023Review
- Astrocytic modulation of neuronal signalling.Frontiers in network physiology · 2023Review
- Controlling synchronization of gamma oscillations by astrocytic modulation in a model hippocampal neural network.Scientific reports · 2022Article
- Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays.Advanced biology · 2021Article
- Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery.Cell stem cell · 2020Review
- Spatiotemporal model of tripartite synapse with perinodal astrocytic process.Journal of computational neuroscience · 2020Article
- Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback.Neural plasticity · 2020Article
- Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction.Neural plasticity · 2020Article
- The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging.Frontiers in aging neuroscience · 2020Article
- A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation.Computational and mathematical methods in medicine · 2020Article
- Vascular and non-vascular contributors to memory reduction during traumatic brain injury.The European journal of neuroscience · 2019Review
- Astrocyte function from information processing to cognition and cognitive impairment.Nature neuroscience · 2019Review
- A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate.Frontiers in computational neuroscience · 2019Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural synchronization is considered as an important mechanism for information processing. In addition, based on recent neurophysiologic findings, it is believed that astrocytes regulate the synaptic transmission of neuronal networks. Therefore, the present study focused on determining the functional contribution of astrocytes in neuronal synchrony using both computer simulations and extracellular field potential recordings. For computer simulations, as a first step, a minimal network model is constructed by connecting two Morris-Lecar neuronal models. In this minimal model, astrocyte-neuron interactions are considered in a functional-based procedure. Next, the minimal network is extended and a biologically plausible neuronal population model is developed which considers functional outcome of astrocyte-neuron interactions too. The employed structure is based on the physiological and anatomical network properties of the hippocampal CA1 area. Utilizing these two different levels of modeling, it is demonstrated that astrocytes are able to change the threshold value of transition from synchronous to asynchronous behavior among neurons. In this way, variations in the interaction between astrocytes and neurons lead to the emergence of synchronous/asynchronous patterns in neural responses. Furthermore, population spikes are recorded from CA1 pyramidal neurons in rat hippocampal slices to validate the modeling results. It demonstrates that astrocytes play a primary role in neuronal firing synchronicity and synaptic coordination. These results may offer a new insight into understanding the mechanism by which astrocytes contribute to stabilizing neural activities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.