ArticlePsychopharmacology2013
Time-dependent effects of haloperidol on glutamine and GABA homeostasis and astrocyte activity in the rat brain.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Effects of gestational haloperidol exposure on mRNA expressions related to glutamate and GABA receptors in offspring.IBRO neuroscience reports · 2023Article
- Investigation of Risperidone Treatment Associated With Enhanced Brain Activity in Patients Who Stutter.Frontiers in neuroscience · 2021Article
- Stuttering: A Disorder of Energy Supply to Neurons?Frontiers in human neuroscience · 2021Article
- Effects of Antipsychotic Drugs: Cross Talk Between the Nervous and Innate Immune System.CNS drugs · 2020Review
- CaNaunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain.Frontiers in neuroscience · 2020Article
- Alterations in glutamatergic signaling in the brain of dopamine supersensitivity psychosis and non-supersensitivity psychosis model rats.Psychopharmacology · 2017Article
- Mind the mortality gap: the importance of metabolic function in mental illnesses.Psychopharmacology · 2013Article
- Metabolic Dysfunction of Astrocyte: An Initiating Factor in Beta-amyloid Pathology?Aging and neurodegeneration · 2013Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleSchizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., Biol Psych 63:759-765, 2008). Since astrocytes play a key role in glutamate metabolism, chronic haloperidol administration was hypothesized to modulate astrocyte metabolic function and glutamate homeostasis.
objectivesThis study investigated the effects of chronic haloperidol administration on astrocyte metabolic activity and glutamate, glutamine, and GABA homeostasis.
methodsWe used ex vivo ¹³C magnetic resonance spectroscopy along with high-performance liquid chromatography after [1-¹³C]glucose and [1,2-¹³C]acetate administration to analyze forebrain tissue from rats administered oral haloperidol for 1 or 6 months.
resultsAdministration of haloperidol for 1 month produced no changes in ¹³C labeling of glutamate, glutamine, or GABA, or in their total levels. However, a 6-month haloperidol administration increased ¹³C labeling of glutamine by [1,2-¹³C]acetate. Moreover, total GABA levels were also increased. Haloperidol administration also increased the acetate/glucose utilization ratio for glutamine in the 6-month cohort.
conclusionsChronic haloperidol administration in rats appears to increase forebrain GABA production along with astrocyte metabolic activity. Studies exploring these processes in subjects with schizophrenia should take into account the potential confounding effects of antipsychotic medication treatment.
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