ArticleFree radical biology & medicine2013
Efficient nitrosation of glutathione by nitric oxide.
Article in Free radical biology & medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Mycothiol maintains the homeostasis and signalling of nitric oxide in Streptomyces coelicolor A3(2) M145.BMC microbiology · 2023Article
- Unraveling the Molecular Mechanism ofInorganic chemistry · 2023Article
- One Stone Two Birds: Redox-Sensitive Colocalized Delivery of Cisplatin and Nitric Oxide through Cascade Reactions.JACS Au · 2022Article
- Nitric oxide storage levels modulate vasodilation and the hypotensive effect induced by photobiomodulation using an aluminum gallium arsenide (AlGaAs) diode laser (660 nm).Lasers in medical science · 2022Article
- Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer's Disease.Molecular neurobiology · 2022Review
- Glutathione in Protein Redox Modulation through S-Glutathionylation and S-Nitrosylation.Molecules (Basel, Switzerland) · 2021Review
- Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders.Neurochemical research · 2020Review
- Endogenous Biosynthesis of S-Nitrosoglutathione From Nitro-Fatty Acids in Plants.Frontiers in plant science · 2020Article
- Comparative and integrative metabolomics reveal thatThe Journal of biological chemistry · 2018Article
- Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance.Molecular pharmacology · 2018Article
- Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted byFrontiers in physiology · 2018Article
- The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state.Nutrition journal · 2016Review
- Postprandial lipids accelerate and redirect nitric oxide consumption in plasma.Nitric oxide : biology and chemistry · 2016Article
- Scavenging of nitric oxide by hemoglobin in the tunica media of porcine coronary arteries.Nitric oxide : biology and chemistry · 2016Article
- Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide.The Journal of biological chemistry · 2015Article
- Aerobic nitric oxide-induced thiol nitrosation in the presence and absence of magnesium cations.Free radical biology & medicine · 2014Article
- Role of ceruloplasmin in nitric oxide metabolism in plasma of humans and sheep: a comparison of adults and fetuses.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
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7 authors.
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Abstract
Nitrosothiols are increasingly regarded as important participants in a range of physiological processes, yet little is known about their biological generation. Nitrosothiols can be formed from the corresponding thiols by nitric oxide in a reaction that requires the presence of oxygen and is mediated by reactive intermediates (NO₂ or N₂O₃) formed in the course of NO autoxidation. Because the autoxidation of NO is second order in NO, it is extremely slow at submicromolar NO concentrations, casting doubt on its physiological relevance. In this paper we present evidence that at submicromolar NO concentrations the aerobic nitrosation of glutathione does not involve NO autoxidation but a reaction that is first order in NO. We show that this reaction produces nitrosoglutathione efficiently in a reaction that is strongly stimulated by physiological concentrations of Mg(2+). These observations suggest that direct aerobic nitrosation may represent a physiologically relevant pathway of nitrosothiol formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.