Trial reportCortex; a journal devoted to the study of the nervous system and behavior
Dissociable fronto-striatal effects of dopamine D2 receptor stimulation on cognitive versus motor flexibility.
Trial report in Cortex; a journal devoted to the study of the nervous system and behavior. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Aging-related changes in cognitive flexibility: fMRI meta-analysis.Behavioral and brain functions : BBF · 2025Pooled it
- Mapping common and distinct brain correlates among cognitive flexibility tasks: concordant evidence from meta-analyses.Brain imaging and behavior · 2025Pooled it
- Increased dopamine availability magnifies nicotine effects on cognitive control: A pilot study.Journal of psychopharmacology (Oxford, England) · 2020Trial
- Effects of tolcapone and bromocriptine on cognitive stability and flexibility.Psychopharmacology · 2018Trial
- Genetic Variations in the Dopaminergic Signaling Pathways and Their Implications for Antipsychotics Pharmacogenetics.Journal of molecular neuroscience : MN · 2026Review
- Dopaminergic drugs modulate fear extinction-related processes in humans, but effects are mild.Brain communications · 2025Article
- Noradrenergic alpha-2a receptor stimulation enhances prediction error signaling and updating of attention sets in anterior cingulate cortex and striatum.Nature communications · 2024Article
- Noradrenergic alpha-2a Receptor Stimulation Enhances Prediction Error Signaling in Anterior Cingulate Cortex and Striatum.bioRxiv : the preprint server for biology · 2023Article
- Parallel learning and cognitive flexibility impairments betweenFrontiers in behavioral neuroscience · 2022Article
- Effective connectivity underlying reward-based executive control.Human brain mapping · 2021Article
- Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia.Nature communications · 2021Article
- Flexible Emotion Regulation: How Situational Demands and Individual Differences Influence the Effectiveness of Regulatory Strategies.Frontiers in psychology · 2019Review
- The Influence of Dopamine on Cognitive Flexibility Is Mediated by Functional Connectivity in Young but Not Older Adults.Journal of cognitive neuroscience · 2018Article
- Controlling striatal function via anterior frontal cortex stimulation.Scientific reports · 2018Article
- Mechanisms of Cognitive Aging in the HIV-Positive Adult.Current behavioral neuroscience reports · 2017Article
- Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?Journal of systems and integrative neuroscience · 2017Article
- Cholinergic, But Not Dopaminergic or Noradrenergic, Enhancement Sharpens Visual Spatial Perception in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors.Frontiers in cellular neuroscience · 2017Review
- Individual differences in the bilingual brain: The role of language background andJournal of neurolinguistics · 2016Article
- Pharmacological Fingerprints of Contextual Uncertainty.PLoS biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Genetic and pharmacological studies suggest an important role of the dopamine D2 receptor (DRD2) in flexible behavioral adaptation, mostly shown in reward-based learning paradigms. Recent evidence from imaging genetics indicates that also intentional cognitive flexibility, associated with lateral frontal cortex, is affected by variations in DRD2 signaling. In the present functional magnetic resonance imaging (MRI) study, we tested the effects of a direct pharmacological manipulation of DRD2 stimulation on intentional flexibility in a task-switching context, requiring switches between cognitive task rules and between response hands. In a double blind, counterbalanced design, participants received either a low dose of the DRD2 agonist bromocriptine or a placebo in two separate sessions. Bromocriptine modulated the blood-oxygen-level-dependent (BOLD) signal during rule switching: rule-switching-related activity in the left posterior lateral frontal cortex and in the striatum was increased compared to placebo, at comparable performance levels. Fronto-striatal connectivity under bromocriptine was slightly increased for rule switches compared to rule repetitions. Hand-switching-related activity, in contrast, was reduced under bromocriptine in sensorimotor regions. Our results provide converging evidence for an involvement of DRD2 signaling in fronto-striatal mechanisms underlying intentional flexibility, and indicate that the neural mechanisms underlying different types of flexibility (cognitive vs motor) are affected differently by increased dopaminergic stimulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.