ArticleThyroid : official journal of the American Thyroid Association2013
Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma.
Article in Thyroid : official journal of the American Thyroid Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 11 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 11 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The associations between sedentary behavior and risk of depression: a systematic review and dose response meta-analysis.BMC public health · 2025Pooled it
- Investigating the Association Between rs2439302 Polymorphism and Thyroid Cancer: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- The associations between screen time-based sedentary behavior and depression: a systematic review and meta-analysis.BMC public health · 2019Pooled it
- Exploration of the association between FOXE1 gene polymorphism and differentiated thyroid cancer: a meta-analysis.BMC medical genetics · 2018Pooled it
- Validation of Polygenic Scores for QT Interval in Clinical Populations.Circulation. Cardiovascular genetics · 2017Pooled it
- rs965513 polymorphism as a common risk marker is associated with papillary thyroid cancer.Oncotarget · 2016Pooled it
- Replication and Meta-Analysis of Common Gene Mutations in TTF1 and TTF2 with Papillary Thyroid Cancer.Medicine · 2015Pooled it
- Common genetic variant on 14q13.3 contributes to thyroid cancer susceptibility: evidence based on 12 studies.Molecular genetics and genomics : MGG · 2015Pooled it
- Associations between rs965513/rs944289 and papillary thyroid carcinoma risk: a meta-analysis.Endocrine · 2014Pooled it
- Common genetic variants on FOXE1 contributes to thyroid cancer susceptibility: evidence based on 16 studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Quantitative assessment of common genetic variants on FOXE1 and differentiated thyroid cancer risk.PloS one · 2014Pooled it
- The FOXE1 rs965513 polymorphism: a pleiotropic risk locus associated with thyroid function, BRAFScientific reports · 2026Article
- Chromosomal localization of mutated genes in non-syndromic familial thyroid cancer.Frontiers in oncology · 2024Review
- Genetic signature of differentiated thyroid carcinoma susceptibility: a machine learning approach.European thyroid journal · 2022Article
- Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Genetic susceptibility to hereditary non-medullary thyroid cancer.Hereditary cancer in clinical practice · 2022Review
- Article
- Genome-wide identification of m6A-associated functional SNPs as potential functional variants for thyroid cancer.American journal of cancer research · 2021Article
- Association analysis between the interaction of RAS family genes mutations and papillary thyroid carcinoma in the Han Chinese population.International journal of medical sciences · 2021Observational
- Network-Based Analysis Reveals Association of FOXE1 Gene Polymorphisms in Thyroid Cancer Patients; A Case-Control Study in Southeast of Iran.Asian Pacific journal of cancer prevention : APJCP · 2020Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundTwo recent genome-wide association studies (GWASs) identified five single nucleotide polymorphisms (SNPs; rs965513, rs944289, rs966423, rs2439302, and rs116909374) associated with papillary thyroid carcinoma (PTC). Each variant showed highly significant but moderate to low disease risk. Here we assessed the cumulative risk and predictive value of the five SNPs.
methodsWe genotyped two cohorts of individuals, 747 PTC cases and 1047 controls from Ohio and 1795 PTC cases and 2090 controls from Poland. Cumulative genetic risk scores were calculated using unweighted and weighted approaches.
resultsAll five SNPs showed significant association with PTC. The average cumulative risk score in cases was significantly higher than in controls (p<2.2×10(-16)). Each additional risk allele increased the risk of having PTC by 1.51 [95% confidence interval (CI) 1.4, 1.64] in Ohio and by 1.35 [95% CI 1.27, 1.44] in Poland. An analysis was performed weighing risk alleles by effect size and assigning individuals to three weighted risk score groups, low (≤2), medium (2-5), and high (>5). Individuals in the high group were significantly more susceptible to PTC compared with individuals in the low group with an odds ratio of 8.7 [95% CI 5.8, 13.3] in Ohio and 4.24 [95% CI 3.10, 5.84] in Poland. Almost identical results were obtained when follicular variant PTCs and microPTCs were omitted. These five SNPs explained 11% of the familial risk of thyroid cancer in the Ohio cohort and 6% in the Polish cohort.
conclusionAs the genetic risk score increases, the risk of having PTC increases. However, the predictive power of the cumulative effect of these five variants is only moderately high and clinical use may not be feasible until more variants are detected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.