ArticleImmunology2013
Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-α, interferon-γ and interleukin-12.
Article in Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 63 citations in OpenAlex.
- Peptide-adaptive NK cell memory in the absence of functional TCR genes.ImmunoHorizons · 2026Article
- Natural killer cell-mediated contact dermatitis-like reaction induced by treatment with TLR3 ligand poly(I:C).Contact dermatitis · 2023Article
- The application of autologous cancer immunotherapies in the age of memory-NK cells.Frontiers in immunology · 2023Review
- Innate Immune Mechanisms in Contact Dermatitis.Handbook of experimental pharmacology · 2022Article
- CXCR6Frontiers in immunology · 2022Article
- NK cell memory: discovery of a mystery.Nature immunology · 2021Article
- Phenotypic and Functional Plasticity of CXCR6Frontiers in immunology · 2021Article
- Memory like NK cells display stem cell like properties after Zika virus infection.PLoS pathogens · 2020Article
- Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells.World journal of gastroenterology · 2020Review
- Tissue-resident memory-like ILCs: innate counterparts of TProtein & cell · 2020Review
- Molecular Regulation of NK Cell Maturation.Frontiers in immunology · 2020Review
- Human natural killer cells mediate adaptive immunity to viral antigens.Science immunology · 2019Article
- CXCR6Frontiers in immunology · 2019Article
- Hepatic Natural Killer Cells: Organ-Specific Sentinels of Liver Immune Homeostasis and Physiopathology.Frontiers in immunology · 2019Review
- Successful development of methodology for detection of hapten-specific contact hypersensitivity (CHS) memory in swine.PloS one · 2019Article
- CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.Cell reports · 2018Article
- Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Friend retrovirus infection induces the development of memory-like natural killer cells.Retrovirology · 2018Article
- Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Natural Killer Cells in Vaccination.Cold Spring Harbor perspectives in biology · 2018Review
- Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Vaccination Strategies Based on NK Cell and ILC Memory.Cold Spring Harbor perspectives in biology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Natural killer (NK) cell-mediated contact sensitivity was recently described in mice. Here, we confirm NK cell-mediated contact sensitivity (CS) in SCID and RAG1(-/-) mice but not in SCIDbeige mice, which have non-functional NK cells that lack NK cell granules. NK cell-mediated CS was transferred by liver mononuclear cells and the DX5(+) fraction of liver cells, confirming that NK cells mediate CS in the absence of T and B cells. Participation of NKT cells and B-1 cells was ruled out using Jα18(-/-) and JH(-/-) mice, respectively. Remarkably, NK cell-mediated CS was observed just 1 hr after immunization and was detectable as early as 30 min after challenge. Further, we examined cytokine requirements for NK cell-mediated CS, and found that liver mononuclear cells from interleukin-12(-/-) , interferon-γ(-/-) and interferon-α receptor(-/-) donors fail to transfer NK cell-mediated CS to naive hosts. Our studies clearly show that dinitrofluorobenzene sensitized NK cells mediate very rapid, antigen-specific cell-mediated immunity, with features of both innate and acquired immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.