Evidence map›Paper›PMID 23659636›Full record

ArticleAnnals of the New York Academy of Sciences2013

Application of combined omics platforms to accelerate biomedical discovery in diabesity.

Irwin J Kurland, Domenico Accili, Charles Burant, Steven M Fischer, Barbara B Kahn, Christopher B Newgard, Suma Ramagiri, Gabriele V Ronnett, John A Ryals, Mark Sanders and 3 more

Abstract readConference Proceedings
In one paragraph

Article in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Metabolomics in the developmental origins of obesity and its cardiometabolic consequences.Journal of developmental origins of health and disease · 2015
    Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Irwin J KurlandDepartment of Medicine, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine Diabetes Center, Bronx, New York 10461, USA.
Domenico Accili
Charles Burant
Steven M Fischer
Barbara B Kahn
Christopher B Newgard
Suma Ramagiri
Gabriele V Ronnett
John A Ryals
Mark Sanders
Joe Shambaugh
John Shockcor
Steven S Gross

Funding

Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Stem Cell-Based Therapies for Radiation-Induced Gastrointestinal Sydrome (RIGS)U19AI091175 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GUHA, CHANDAN · 2010 to 2014
$13.1M
Risk Genes and Environment Interactions in NTDsP01HD067244 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSS, MARGARET ELIZABETH · 2011 to 2020
$12.6M
Glucose Transporter Regulation in Obesity and DiabetesR37DK043051 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAHN, BARBARA B. · 2006 to 2015
$5.0M
MOUSE MODELS OF INSULIN RESISTANCER37DK058282 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ACCILI, DOMENICO · 2010 to 2019
$4.4M
Diabetic Vasculopathy and Mitochondrial eNOSR37HL087062 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GROSS, STEVEN S · 2007 to 2016
$4.2M
Hepatic Insuling Action: Role of the Pentose CycleR01DK058132 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURLAND, IRWIN JACK · 2002 to 2011
$3.4M
NHLBI NIH HHS R37 HL087062NIAID NIH HHS 1U19AI091175NIAID NIH HHS U19 AI091175NICHD NIH HHS P01 HD067244NIDDK NIH HHS 2R01DK058132NIDDK NIH HHS 3R37DK058282NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P60 DK020541NIDDK NIH HHS P60DK020541NIDDK NIH HHS R01 DK058132NIDDK NIH HHS R37 DK043051NIDDK NIH HHS R37 DK058282
6 · The paper itself

Abstract

Diabesity has become a popular term to describe the specific form of diabetes that develops late in life and is associated with obesity. While there is a correlation between diabetes and obesity, the association is not universally predictive. Defining the metabolic characteristics of obesity that lead to diabetes, and how obese individuals who develop diabetes different from those who do not, are important goals. The use of large-scale omics analyses (e.g., metabolomic, proteomic, transcriptomic, and lipidomic) of diabetes and obesity may help to identify new targets to treat these conditions. This report discusses how various types of omics data can be integrated to shed light on the changes in metabolism that occur in obesity and diabetes.

Indexed as

Computational BiologyAdultAgedAnimalsCardiovascular DiseasesComorbidityDiabetes Mellitus, Type 2Disease Models, AnimalDrug DiscoveryEnergy MetabolismFemaleGlucoseHumansInsulin ResistanceLipid MetabolismMaleGlucose

Identifiers

PMID23659636
PMCPMC3709136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.