ArticleBreast cancer research : BCR2013
Pregnancy protection of breast cancer: new insights reveal unanswered questions.
Article in Breast cancer research : BCR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Alcoholic beverage consumption and female breast cancer risk: A systematic review and meta-analysis of prospective cohort studies.Alcohol, clinical & experimental research · 2024Review
- Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions.Nature communications · 2020Article
- Physical activity from menarche to first pregnancy and risk of breast cancer.International journal of cancer · 2016Article
- Links between alcohol consumption and breast cancer: a look at the evidence.Women's health (London, England) · 2015Review
- Breast cancer risk accumulation starts early: prevention must also.Breast cancer research and treatment · 2014Review
- Adolescent dietary fiber, vegetable fat, vegetable protein, and nut intakes and breast cancer risk.Breast cancer research and treatment · 2014Article
- Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk.Journal of the National Cancer Institute · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent paper by Meier-Abt and colleagues on pregnancy protection of breast cancer development takes a different approach to the problem and focused on the effect of parity on the cell subpopulations of the mouse mammary gland. Their results demonstrate that parity decreases the cell number of the hormone receptor-positive luminal cells (that is, luminal Sca1+) but not the basal stem/progenitor cells (CD24lo/CD49hi). Additionally, microarray studies demonstrate that wnt4 expression from the luminal Sca1+ cells is markedly reduced as is the wnt signaling pathway in basal cells. One important implication from these results is that targeting the wnt signaling pathway might be a feasible prevention approach in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.