ArticleJournal of natural products2013
Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa.
Article in Journal of natural products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cell Death Induced by Homoisoflavonoid Brazilin and Its Semisynthetic Derivatives on MDA-MB-231 and MCF7 Breast Cancer Cell Lines.ACS omega · 2026Article
- Anti-inflammatory constituents isolated from the flowers ofRSC advances · 2023Article
- Isolation and Biological Characterization of Homoisoflavanoids and the AlkylamideBiomolecules · 2021Article
- A Comprehensive Review on Chemotaxonomic and Phytochemical Aspects of Homoisoflavonoids, as Rare Flavonoid Derivatives.International journal of molecular sciences · 2021Review
- Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity.Journal of natural medicines · 2020Article
- Identification by Molecular Docking ofHomoisoflavones from Leopoldia comosa as Ligands of Estrogen Receptors.Molecules (Basel, Switzerland) · 2018Article
- Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense.Journal of natural products · 2015Article
- Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds.Bioorganic & medicinal chemistry · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
Investigation of the South African plant Urginea depressa Baker (Asparagaceae Juss.) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the six new homoisoflavonoids urgineanins A-F (1-6), the two known bufatrienolides 7 and 9, and the new bufatrienolides urginins B and C (8 and 10). Structures were elucidated based on analysis of their 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometric data. Five of the six new homoisoflavonoids had good antiproliferative activity against the A2780 ovarian cancer, A2058 melanoma, and H522-T1 human non-small-cell lung cancer cells, and urgineanin A (1) had submicromolar activity against all three cell lines. The four bufatrienolides 7-10 had strong antiproliferative activity against the same cell line, with IC50 values of 24.1, 11.2, 111, and 40.6 nM, respectively.
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