ArticleBiology of mood & anxiety disorders2013
Anxiety genetics - findings from cross-species genome-wide approaches.
Article in Biology of mood & anxiety disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- New perspectives on stress and negative emotions: Positive effects on adolescent learning, memory, and mental health.PloS one · 2025Article
- Primary hyperhidrosis: From a genetics point of view.Journal of family medicine and primary care · 2023Review
- Genetics of behavioural evolution in giant mice from Gough Island.Proceedings. Biological sciences · 2023Article
- Evolution of Boldness and Exploratory Behavior in Giant Mice from Gough Island.Behavioral ecology and sociobiology · 2021Article
- Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds.Genetics, selection, evolution : GSE · 2019Article
- Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior.PLoS genetics · 2019Article
- Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Biological underpinnings of psychogenic nonepileptic seizures: directions for future research.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Review
- Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014.Psychiatric genetics · 2016Article
- Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Frontiers in psychiatry · 2015Review
- Genetic influences on brain gene expression in rats selected for tameness and aggression.Genetics · 2014Article
- From Pavlov to PTSD: the extinction of conditioned fear in rodents, humans, and anxiety disorders.Neurobiology of learning and memory · 2014Review
- Translational approaches to anxiety: focus on genetics, fear extinction and brain imaging.Current psychiatry reports · 2013Review
- The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders.Frontiers in pharmacology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders are complex diseases, which often occur in combination with major depression, alcohol use disorder, or general medical conditions. Anxiety disorders were the most common mental disorders within the EU states in 2010 with 14% prevalence. Anxiety disorders are triggered by environmental factors in genetically susceptible individuals, and therefore genetic research offers a great route to unravel molecular basis of these diseases. As anxiety is an evolutionarily conserved response, mouse models can be used to carry out genome-wide searches for specific genes in a setting that controls for the environmental factors. In this review, we discuss translational approaches that aim to bridge results from unbiased genome-wide screens using mouse models to anxiety disorders in humans. Several methods, such as quantitative trait locus mapping, gene expression profiling, and proteomics, have been used in various mouse models of anxiety to identify genes that regulate anxiety or play a role in maintaining pathological anxiety. We first discuss briefly the evolutionary background of anxiety, which justifies cross-species approaches. We then describe how several genes have been identified through genome-wide methods in mouse models and subsequently investigated in human anxiety disorder samples as candidate genes. These studies have led to the identification of completely novel biological pathways that regulate anxiety in mice and humans, and that can be further investigated as targets for therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.