ArticleJournal of natural products2013
Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).
Article in Journal of natural products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Ireland-Claisen Rearrangement as a Stereocontrolled Bond-Construction Strategy in Natural Product Total Synthesis.ACS omega · 2026Review
- Repositioning Brusatol as a Transmission Blocker of Malaria Parasites.ACS infectious diseases · 2024Article
- Therapeutic Opportunities in Breast Cancer by Targeting Macrophage Migration Inhibitory Factor as a Pleiotropic Cytokine.Breast cancer : basic and clinical research · 2024Review
- Natural-product-based fluorescent probes: recent advances and applications.RSC medicinal chemistry · 2023Review
- Site-directed late-stage diversification of macrocyclic nannocystins facilitating anticancer SAR and mode of action studies.RSC medicinal chemistry · 2023Article
- Atypical Spirotetronate Polyketides Identified in the Underexplored GenusThe Journal of organic chemistry · 2020Article
- Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor.Journal of medicinal chemistry · 2018Article
- Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile.ACS infectious diseases · 2018Article
- Ritterostatin GChembiochem : a European journal of chemical biology · 2017Article
- Single dish gradient screening of small molecule localization.Organic & biomolecular chemistry · 2016Article
- Chemical proteomics approaches for identifying the cellular targets of natural products.Natural product reports · 2016Review
- Spirotetronate polyketides as leads in drug discovery.Journal of natural products · 2015Review
- Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Spirohexenolides A and B comprise a unique family of spirotetronate natural products. We report on the identification of their binding to and modulation of human macrophage migration inhibitor factor (hMIF). Using an immunoaffinity-fluorescent labeling method, the properties of this interaction are detailed and evidence is provided that hMIF plays a key role in the cytostatic activity of the spirohexenolides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.