ArticlePloS one2013
Secretome analysis defines the major role of SecDF in Staphylococcus aureus virulence.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Potential Therapeutic Targets for Combination Antibody Therapy AgainstAntibiotics (Basel, Switzerland) · 2024Review
- Response ofJournal of bacteriology · 2024Article
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- Limited Adaptation ofMicrobiology spectrum · 2023Article
- Review
- Identification of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Methods for Using the Galleria mellonella Invertebrate Model to Probe Enterococcus faecalis Pathogenicity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Review
- Article
- Staphylococcal Protein Secretion and Envelope Assembly.Microbiology spectrum · 2019Review
- Septal secretion of protein A ineLife · 2018Article
- The ArlRS two-component system is a regulator of Staphylococcus aureus-induced endothelial cell damage.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing.Virulence · 2016Review
- Evolutionary evidence on suitability of SecD as a target for development of antibacterial agents against Staphylococcus aureus.Ecology and evolution · 2016Article
- The Staphylococcus aureus Chaperone PrsA Is a New Auxiliary Factor of Oxacillin Resistance Affecting Penicillin-Binding Protein 2A.Antimicrobial agents and chemotherapy · 2015Article
- Sec pathway influences the growth of Deinococcus radiodurans.Current microbiology · 2015Article
- Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria.Biochimica et biophysica acta · 2014Review
- SecDF as part of the Sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins.PloS one · 2014Article
- The Aeromonas salmonicida subsp. salmonicida exoproteome: global analysis, moonlighting proteins and putative antigens for vaccination against furunculosis.Proteome science · 2013Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Sec pathway plays a prominent role in protein export and membrane insertion, including the secretion of major bacterial virulence determinants. The accessory Sec constituent SecDF has been proposed to contribute to protein export. Deletion of Staphylococcus aureus secDF has previously been shown to reduce resistance, to alter cell separation, and to change the expression of certain virulence factors. To analyse the impact of the secDF deletion in S. aureus on protein secretion, a quantitative secretome analysis was performed. Numerous Sec signal containing proteins involved in virulence were found to be decreased in the supernatant of the secDF mutant. However, two Sec-dependent hydrolases were increased in comparison to the wild type, suggesting additional indirect, regulatory effects to occur upon deletion of secDF. Adhesion, invasion, and cytotoxicity of the secDF mutant were reduced in human umbilical vein endothelial cells. Virulence was significantly reduced using a Galleria mellonella insect model. Altogether, SecDF is a promising therapeutic target for controlling S. aureus infections.
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