ArticlePloS one2013
Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 130 citations in OpenAlex.
- The tiger salamander as a promising alternative model organism to the axolotl for fracture healing and regenerative biology research.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Temporal changes in gene regulation during human tissue repair.Scientific reports · 2026Article
- VEGF signaling promotes blastema growth and proliferation of vascular and non-vascular cells during axolotl limb regeneration.Developmental biology · 2025Article
- An axolotl limb regeneration-inspired strategy to enhance alveolar bone regeneration.Bioactive materials · 2025Article
- Sall4 regulates downstream patterning genes during limb regeneration.Developmental biology · 2024Article
- Explosive regeneration and anamorphic development of legs in the house centipede Scutigera coleoptrata.Frontiers in zoology · 2024Article
- Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms.bioRxiv : the preprint server for biology · 2024Article
- Time-course swRNA-seq uncovers a hierarchical gene regulatory network in controlling the response-repair-remodeling after wounding.Communications biology · 2024Article
- Making a new limb out of old cells: exploring endogenous cell reprogramming and its role during limb regeneration.American journal of physiology. Cell physiology · 2024Review
- Key Proteins for Regeneration inScientifica · 2024Article
- Multi-species atlas resolves an axolotl limb development and regeneration paradox.Nature communications · 2023Article
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- Limb blastema formation: How much do we know at a genetic and epigenetic level?The Journal of biological chemistry · 2023Review
- Local problems need global solutions: The metabolic needs of regenerating organisms.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Review
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- Rebuilding limbs, one cell at a time.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
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- Article
- Tig1 regulates proximo-distal identity during salamander limb regeneration.Nature communications · 2022Article
- Wnt Signaling Coordinates the Expression of Limb Patterning Genes During Axolotl Forelimb Development and Regeneration.Frontiers in cell and developmental biology · 2022Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how the limb blastema is established after the initial wound healing response is an important aspect of regeneration research. Here we performed parallel expression profile time courses of healing lateral wounds versus amputated limbs in axolotl. This comparison between wound healing and regeneration allowed us to identify amputation-specific genes. By clustering the expression profiles of these samples, we could detect three distinguishable phases of gene expression - early wound healing followed by a transition-phase leading to establishment of the limb development program, which correspond to the three phases of limb regeneration that had been defined by morphological criteria. By focusing on the transition-phase, we identified 93 strictly amputation-associated genes many of which are implicated in oxidative-stress response, chromatin modification, epithelial development or limb development. We further classified the genes based on whether they were or were not significantly expressed in the developing limb bud. The specific localization of 53 selected candidates within the blastema was investigated by in situ hybridization. In summary, we identified a set of genes that are expressed specifically during regeneration and are therefore, likely candidates for the regulation of blastema formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.