ArticlePloS one2013
Dynamics of specific anti-Mycobacterium avium subsp. paratuberculosis antibody response through age.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Estimated true prevalence and associated risk factors of bovine paratuberculosis antibodies in dairy herds in Bangladesh.PloS one · 2026Article
- Age-adjusted ELISA cutoffs for Johne's disease in young adult dairy cattle using Bayesian nonparametric models.Frontiers in veterinary science · 2026Article
- Bayesian Assessment of True Prevalence of Paratuberculosis Infection in Dairy Herds and Their Parity Subgroups.Pathogens (Basel, Switzerland) · 2025Article
- Individual- and Herd-Level Milk ELISA Test Status and Incidence for Paratuberculosis in Hubei Province, China.Veterinary sciences · 2024Article
- Article
- Presence of antibodies against Mycobacterium avium subspecies paratuberculosis in Brazilian high-producing dairy herds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Narrative Review Comparing Principles and Instruments Used in Three Active Surveillance and Control Programmes for Non-EU-regulated Diseases in the Danish Cattle Population.Frontiers in veterinary science · 2021Review
- Modelling spread and surveillance of Mycobacterium avium subsp. paratuberculosis in the Swedish cattle trade network.Preventive veterinary medicine · 2020Article
- The Effect ofAnimals : an open access journal from MDPI · 2020Article
- Evaluating the impact of transmission mode, calibration level and farmer compliance in simulation models of paratuberculosis in dairy herds.Scientific reports · 2018Article
- Identifying individual animal factors associated with Mycobacterium avium subsp. paratuberculosis (MAP) milk ELISA positivity in dairy cattle in the Midwest region of the United States.BMC veterinary research · 2018Article
- A data-driven individual-based model of infectious disease in livestock operation: A validation study for paratuberculosis.PloS one · 2018Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): paratuberculosis.EFSA journal. European Food Safety Authority · 2017Article
- Moving past serology: Diagnostic options without serum.Veterinary journal (London, England : 1997) · 2016Review
- Article
- Simulating the Epidemiological and Economic Impact of Paratuberculosis Control Actions in Dairy Cattle.Frontiers in veterinary science · 2016Article
- Mean effective sensitivity for Mycobacterium avium subsp. paratuberculosis infection in cattle herds.BMC veterinary research · 2015Article
- An immuno-epidemiological model for Johne's disease in cattle.Veterinary research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium avium subsp. paratuberculosis (MAP) causes a chronic infection in cattle. MAP infected cattle with humoral immune (HI) reactions with IgG antibodies are usually those where latency of infection has ceased and their infection is progressing towards reduced milk yield, weight loss and significant bacterial excretion in feces. The proportion of detectable infections among all infected animals that will develop disease is often referred to as 'the tip of the iceberg'. The purpose of this study was to estimate this proportion. Test-records from 18,972 Danish dairy cows with MAP specific IgG antibodies on their final test-record were used to estimate age-specific sensitivities (Se). These cows were the infected ones considered to develop disease in a population with a representative age-distribution and were defined as cases. The specificity (Sp) of the test was estimated based on test-results from 166,905 cows, which had no MAP IgG antibodies in their final four test-records. The Sp, age-specific Se and maximum Se were used to estimate the probability of having HI at a given age resulting in the proportion of infected cows with HI at a given age. For cows 2 years of age, the proportion of detectable cases was 0.33, while it was 0.94 for cows 5 years of age. Thus, there was a significant shift in the tip of the iceberg with aging. This study provided a model for estimating the proportion of latent chronic infections that would progress to disease, and the results can be used to model infection dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.