ArticlePloS one2013
Development of autoimmune hair loss disease alopecia areata is associated with cardiac dysfunction in C3H/HeJ mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association between alopecia areata and cardiovascular disease: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Metabolic and Vascular Inflammation in Alopecia Areata: Linking Uric Acid, Lipid Imbalance and ICAM-1 Upregulation.Experimental dermatology · 2025Article
- Evaluation of Anthropometric Measurements, Arterial Stiffness and ECG Parameters in Alopecia Areata Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Is the severity of alopecia areata associated with arterial stiffness?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α.Frontiers in immunology · 2022Article
- Electrocardiogram Findings in Patients with Alopecia Areata.Dermatology and therapy · 2021Article
- Genomic Regions Associated with the Position and Number of Hair Whorls in Horses.Animals : an open access journal from MDPI · 2021Article
- Current insight into the functions of microRNAs in common human hair loss disorders: a mini review.Human cell · 2021Review
- Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study.PloS one · 2021Article
- Integrated multi-omics analysis of genomics, epigenomics, and transcriptomics in ovarian carcinoma.Aging · 2019Article
- Proteomic analysis reveals distinctive protein profiles involved in CD8Cellular & molecular immunology · 2018Article
- Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata.Journal of clinical laboratory analysis · 2018Article
- Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways.Genes and immunity · 2017Article
- Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Alopecia areata (AA) is a chronic autoimmune hair loss disease that affects several million men, women and children worldwide. Previous studies have suggested a link between autoimmunity, stress hormones, and increased cardiovascular disease risk. In the current study, histology, immunohistology, quantitative PCR (qPCR) and ELISAs were used to assess heart health in the C3H/HeJ mouse model for AA and heart tissue response to adrenocorticotropic hormone (ACTH) exposure. Mice with AA exhibited both atrial and ventricular hypertrophy, and increased collagen deposition compared to normal-haired littermates. QPCR revealed significant increases in Il18 (4.6-fold), IL18 receptor-1 (Il18r1; 2.8-fold) and IL18 binding protein (Il18bp; 5.2-fold) in AA hearts. Time course studies revealed a trend towards decreased Il18 in acute AA compared to controls while Il18r1, Il18bp and Casp1 showed similar trends to those of chronic AA affected mice. Immunohistochemistry showed localization of IL18 in chronic AA mouse atria. ELISA indicated cardiac troponin-I (cTnI) was elevated in the serum and significantly increased in AA heart tissue. Cultures of heart atria revealed differential gene expression between AA and control mice in response to ACTH. ACTH treatment induced significant increase in cTnI release into the culture medium in a dose-dependent manner for both AA and control mice. In conclusion, murine AA is associated with structural, biochemical, and gene expression changes consistent with cardiac hypertrophy in response to ACTH exposure.
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Registered trials
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