ArticlePloS one2013
Peripheral monocyte functions and activation in patients with quiescent Crohn's disease.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Mapping the Impact of Janus Kinase Inhibitors at a Cellular Resolution in Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2026Review
- Macrophage-Orchestrated Metabolic Sensing Drives IBD Pathogenesis: A Framework for Targeted Therapy.International journal of biological sciences · 2026Review
- Identifying Cellular Neighborhood Phenotypes Differentiating Normal and Quiescent Crohn's Disease via MxIF.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Peripheral monocytes from Crohn's disease patients retain functional responsiveness to GM-CSF during active disease.Frontiers in immunology · 2025Article
- Alteration of monocyte subsets and their functions in thalassemia patients.International journal of hematology · 2023Article
- Monocytosis Is a Biomarker of Severity in Inflammatory Bowel Disease: Analysis of a 6-Year Prospective Natural History Registry.Inflammatory bowel diseases · 2022Article
- Targeting Immune Cell Metabolism in the Treatment of Inflammatory Bowel Disease.Inflammatory bowel diseases · 2021Review
- Understanding the Molecular Drivers of Disease Heterogeneity in Crohn's Disease Using Multi-omic Data Integration and Network Analysis.Inflammatory bowel diseases · 2021Article
- Is there a relation between vitamin D, interleukin-17, and bone mineral density in patients with inflammatory bowel disease?Archives of medical science : AMS · 2021Article
- Macrophage polarization in intestinal inflammation and gut homeostasis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Review
- Identification of key pathways and genes shared between Crohn's disease and breast cancer using bioinformatics analysis.Oncology letters · 2020Article
- Whole-Genome DNA Methylation Profiling of CD14+ Monocytes Reveals Disease Status and Activity Differences in Crohn's Disease Patients.Journal of clinical medicine · 2020Article
- Article
- Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD.Nature reviews. Gastroenterology & hepatology · 2019Review
- CSF-1 regulates the function of monocytes in Crohn's disease patients in remission.Scientific reports · 2017Article
- The Effects of Hypoxia on U937 Cell Line in Mesenchymal Stem Cells Co-Culture System.Advanced pharmaceutical bulletin · 2016Article
- Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.Nature communications · 2016Article
- GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn's disease.Molecular and cellular pediatrics · 2015Article
- Granulocyte Macrophage Colony-Stimulating Factor-Activated CD39Cellular and molecular gastroenterology and hepatology · 2015Article
- LPS-Stimulated Whole Blood Cytokine Production Is Not Related to Disease Behavior in Patients with Quiescent Crohn's Disease.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent developments suggest a causal link between inflammation and impaired bacterial clearance in Crohn's disease (CD) due to alterations of intestinal macrophages. Studies suggest that excessive inflammation is the consequence of an underlying immunodeficiency rather than the primary cause of CD pathogenesis. We characterized phenotypic and functional features of peripheral blood monocytes of patients with quiescent CD (n = 18) and healthy controls (n = 19) by analyses of cell surface molecule expression, cell adherence, migration, chemotaxis, phagocytosis, oxidative burst, and cytokine expression and secretion with or without lipopolysaccharide (LPS) priming. Peripheral blood monocytes of patients with inactive CD showed normal expression of cell surface molecules (CD14, CD16, CD116), adherence to plastic surfaces, spontaneous migration, chemotaxis towards LTB4, phagocytosis of E. coli, and production of reactive oxygen species. Interestingly, peripheral blood monocytes of CD patients secreted higher levels of IL1β (p<.05). Upon LPS priming we found a decreased release of IL10 (p<.05) and higher levels of CCL2 (p<.001) and CCL5 (p<.05). The expression and release of TNFα, IFNγ, IL4, IL6, IL8, IL13, IL17, CXCL9, and CXCL10 were not altered compared to healthy controls. Based on our phenotypic and functional studies, peripheral blood monocytes from CD patients in clinical remission were not impaired compared to healthy controls. Our results highlight that defective innate immune mechanisms in CD seems to play a role in the (inflamed) intestinal mucosa rather than in peripheral blood.
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