ArticlePloS one2013
Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- DISC1 mutant macaques capture behavioral and neural hallmarks of psychiatric disease.National science review · 2026Article
- 13-Month Follow Up of Acclimation of Cynomolgus Macaques (Macaca fascicularis) on Haematology, Serum Biochemistry, and Body Weight Changes.Journal of medical primatology · 2025Article
- Differential pathological dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in nonhuman primates.Science advances · 2025Article
- Potential Food Inclination of Crab-Eating Macaques in Laboratory Environments: Enhancing Positive Reinforcement Training and Health Optimization.Animals : an open access journal from MDPI · 2024Article
- Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta).PloS one · 2023Article
- Nonhuman primate abnormal behavior: Etiology, assessment, and treatment.American journal of primatology · 2022Review
- Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates.Science advances · 2020Article
- CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms.Human molecular genetics · 2019Article
- BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders.National science review · 2019Article
- Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis).International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018Article
- Dopamine and serotonin modulation of motor and non-motor functions of the non-human primate striato-pallidal circuits in normal and pathological states.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- A cross-species comparison of abnormal behavior in three species of singly-housed old world monkeys.Applied animal behaviour science · 2018Article
- Hypercortisolemia and Depressive-like Behaviors in a Rhesus Macaque (Comparative medicine · 2017Article
- Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.Human molecular genetics · 2015Article
- Social behavioral changes in MPTP-treated monkey model of Parkinson's disease.Frontiers in behavioral neuroscience · 2015Article
- Abnormal behavior and associated risk factors in captive baboons (Papio hamadryas spp.).American journal of primatology · 2014Article
- Depressive-like behavioral response of adult male rhesus monkeys during routine animal husbandry procedure.Frontiers in behavioral neuroscience · 2014Article
- Assessing anxiety in nonhuman primates.ILAR journal · 2014Review
- Review
- Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: a species comparison.Frontiers in behavioral neuroscience · 2014Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, experimental and preclinical studies on neuropsychiatric conditions have almost exclusively been performed in experimentally-induced animal models and have only rarely relied upon an ethological approach where animals have been observed in more naturalistic settings. The laboratory species of choice has been the rodent while the potential of more closely-related non-human primates have remained largely underexplored.
methodsThe present study, therefore, aimed at investigating the possible existence of spontaneous atypical/abnormal behaviours displayed by 40 cynomolgus macaques in captive conditions using an unbiased ethological scan-sampling analysis followed by multifactorial correspondence analysis and a hierarchical clustering.
resultsThe study identified five distinct profiles (groups A to E) that significantly differed on several behaviours, body postures, body orientations, gaze directions and locations in the cage environment. We suggest that animals from the low n groups (D and E) present depressive-like and anxious-like symptoms, reminiscent of depressive and generalized anxiety disorders. Inter-individual differences were highlighted through unbiased ethological observations of spontaneous behaviours and associated parameters, although these were not associated with differences in plasma or cerebrospinal fluid levels of either stress-related hormones or monoamines, i.e. in accordance with the human situation.
conclusionsNo interventional behavioural testing was required to discriminate between 3 typical and 2 atypical ethologically-defined behavioural profiles, reminiscent of certain depressive-like and anxiety-like symptoms. The use of unbiased behavioural observations might, thus, allow the identification of animal models of human mental/behavioural disorders and their most appropriate control groups.
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