ArticlePloS one2013
Novel phylogenetic algorithm to monitor human tropism in Egyptian H5N1-HPAIV reveals evolution toward efficient human-to-human transmission.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 36 citations in OpenAlex.
- Bioinformatics procedure for investigating senolytic (anti-aging) agents: A digital signal processing technique.Aging medicine (Milton (N.S.W)) · 2023Article
- Vaccination and Antiviral Treatment against Avian Influenza H5Nx Viruses: A Harbinger of Virus Control or Evolution.Vaccines · 2023Review
- Novel Entropy-Based Phylogenetic Algorithm: A New Approach for Classifying SARS-CoV-2 Variants.Entropy (Basel, Switzerland) · 2023Article
- Evolution of SARS-CoV-2 virus and assessment of the effectiveness of COVID-19 vaccine.F1000Research · 2021Article
- Evolution of H5-Type Avian Influenza A Virus Towards Mammalian Tropism in Egypt, 2014 to 2015.Pathogens (Basel, Switzerland) · 2019Article
- Unlocking pandemic potential: prevalence and spatial patterns of key substitutions in avian influenza H5N1 in Egyptian isolates.BMC infectious diseases · 2018Article
- Review
- Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues.Frontiers in neuroscience · 2018Article
- Phylodynamics of avian influenza clade 2.2.1 H5N1 viruses in Egypt.Virology journal · 2016Article
- Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China.PloS one · 2016Article
- Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection.F1000Research · 2016Article
- In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses.Scientific reports · 2015Article
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- In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope.Frontiers in neuroscience · 2015Article
- Evolution of 2014/15 H3N2 Influenza Viruses Circulating in US: Consequences for Vaccine Effectiveness and Possible New Pandemic.Frontiers in microbiology · 2015Article
- Epidemiology, ecology and gene pool of influenza A virus in Egypt: will Egypt be the epicentre of the next influenza pandemic?Virulence · 2015Review
- In silico analysis suggests interaction between Ebola virus and the extracellular matrix.Frontiers in microbiology · 2015Article
- Adjuvant efficacy of mOMV against avian influenza virus infection in mice.Journal of microbiology (Seoul, Korea) · 2013Article
- Feature-based classification of amino acid substitutions outside conserved functional protein domains.TheScientificWorldJournal · 2013Article
- Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Years of endemic infections with highly pathogenic avian influenza (HPAI) A subtype H5N1 virus in poultry and high numbers of infections in humans provide ample opportunity in Egypt for H5N1-HPAIV to develop pandemic potential. In an effort to better understand the viral determinants that facilitate human infections of the Egyptian H5N1-HPAIVvirus, we developed a new phylogenetic algorithm based on a new distance measure derived from the informational spectrum method (ISM). This new approach, which describes functional aspects of the evolution of the hemagglutinin subunit 1 (HA1), revealed a growing group G2 of H5N1-HPAIV in Egypt after 2009 that acquired new informational spectrum (IS) properties suggestive of an increased human tropism and pandemic potential. While in 2006 all viruses in Egypt belonged to the G1 group, by 2011 these viruses were virtually replaced by G2 viruses. All of the G2 viruses displayed four characteristic mutations (D43N, S120(D,N), (S,L)129Δ and I151T), three of which were previously reported to increase binding to the human receptor. Already in 2006-2008 G2 viruses were significantly (p<0.02) more often found in humans than expected from their overall prevalence and this further increased in 2009-2011 (p<0.007). Our approach also identified viruses that acquired additional mutations that we predict to further enhance their human tropism. The extensive evolution of Egyptian H5N1-HPAIV towards a preferential human tropism underlines an urgent need to closely monitor these viruses with respect to molecular determinants of virulence.
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