ArticleJournal of virology2013
Contribution of follicular dendritic cells to persistent HIV viremia.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Viral Infection and Dissemination Through the Lymphatic System.Microorganisms · 2025Review
- Modeling the Interplay Between Viral and Immune Dynamics in HIV: A Review and Mrgsolve Implementation and Exploration.Clinical and translational science · 2025Review
- Review
- Article
- Epigenetic Mechanisms of HIV-1 Persistence.Vaccines · 2021Review
- Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques.JCI insight · 2021Article
- Review
- Barriers for HIV Cure: The Latent Reservoir.AIDS research and human retroviruses · 2018Review
- Insight into treatment of HIV infection from viral dynamics models.Immunological reviews · 2018Review
- Peering into the HIV reservoir.Reviews in medical virology · 2018Review
- Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node.Frontiers in immunology · 2018Review
- Landscape review of current HIV 'kick and kill' cure research - some kicking, not enough killing.BMC infectious diseases · 2017Review
- The Lymph Node in HIV Pathogenesis.Current HIV/AIDS reports · 2017Review
- Modeling Kick-Kill Strategies toward HIV Cure.Frontiers in immunology · 2017Review
- Are T cells the only HIV-1 reservoir?Retrovirology · 2016Review
- Impaired B cells survival upon production of inflammatory cytokines by HIV-1 exposed follicular dendritic cells.Retrovirology · 2016Article
- HIV-1 Reservoirs During Suppressive Therapy.Trends in microbiology · 2016Review
- Quantifying the turnover of transcriptional subclasses of HIV-1-infected cells.PLoS computational biology · 2014Article
- Modeling the within-host dynamics of HIV infection.BMC biology · 2013Review
- C-C chemokine receptor-7 mediated endocytosis of antibody cargoes into intact cells.Frontiers in pharmacology · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
HIV-1 infections cannot be completely eradicated by drug therapy, as the virus persists in reservoirs. Low-level plasma viremia has been detected in patients treated for over 7 years, but the cellular compartments that support this low-level viremia have not been identified. The decay of HIV-1 during treatment appears to occur in four phases, with the 3rd and 4th phases occurring when the virus is below the limit of detection of conventional assays. Here, we focus on the 3rd phase of decay, which has been estimated to have a half-life of 39 months. We show that follicular dendritic cells (FDC), which have been identified as an HIV reservoir, can be the main source of the low-level viremia detected during the 3rd phase of decay and contribute to viremia at even longer times. Our calculations show that the kinetics of leakage of virus from FDC is consistent with three types of available clinical data.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.