Evidence map›Paper›PMID 23658391›Full record

ArticleClinical and vaccine immunology : CVI2013

Lack of serum antibodies against Borrelia burgdorferi in children with autism.

Peter D Burbelo, Susan E Swedo, Audrey Thurm, Ahmad Bayat, Andrew E Levin, Adriana Marques, Michael J Iadarola

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED).Autism research : official journal of the International Society for Autism Research · 2019
    Article
  3. Luciferase immunoprecipitation systems for measuring antibodies in autoimmune and infectious diseases.Translational research : the journal of laboratory and clinical medicine · 2015
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Peter D BurbeloNeurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. burbelop@nidcr.nih.gov
Susan E Swedo
Audrey Thurm
Ahmad Bayat
Andrew E Levin
Adriana Marques
Michael J Iadarola
National Institutes of Health · USImmunetics (United States) · USNational Institute of Dental and Craniofacial Research · USNational Institute of Mental Health · US

Funding

Clinical and Behavioral Phenotyping of Autism and Related DisordersZIAMH002868 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SWEDO, SUSAN · 2009 to 2017
$17.8M
Assessment Of Patients With Borrelia InfectionZIAAI000695 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MARQUES, ADRIANA R · 2009 to 2025
$8.8M
Neuroimmunologic Investigations of Autism Spectrum Disorders (ASD)ZIAMH002915 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SWEDO, SUSAN · 2009 to 2014
$1.4M
Mechanisms of Pain and Immune ProcessesZIACL090034 · CLC · CLINICAL CENTER · PI MANNES, ANDREW · 2014 to 2025
$0k
Intramural NIH HHS
6 · The paper itself

Abstract

It has been proposed that Borrelia burgdorferi infection is present in ∼25% of children with autism spectrum disorders. In this study, antibodies against Borrelia burgdorferi were assessed in autistic (n = 104), developmentally delayed (n = 24), and healthy control (n = 55) children. No seropositivity against Borrelia burgdorferi was detected in the children with and without autism. There was no evidence of an association between Lyme disease and autism.

Indexed as

Antibodies, BacterialAutistic DisorderBorrelia burgdorferiChildChild, PreschoolCohort StudiesFemaleHumansInfantLyme DiseaseMaleSeroepidemiologic StudiesSerumAntibodies, Bacterial

Identifiers

PMID23658391
PMCPMC3697448
OpenAlexW2162152417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.