ArticleJournal of clinical microbiology2013
Rapid molecular microbiologic diagnosis of prosthetic joint infection.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 6 of them syntheses that pooled it.
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Who cites it
93 citing papers in PubMed, 6 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Optimized use and performance of culture for periprosthetic joint infection diagnosis: a comprehensive literature review.Clinical microbiology reviews · 2025Pooled it
- Diagnostic accuracy of sonication fluid cultures from prosthetic components in periprosthetic joint infection: an updated diagnostic meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Meta-analysis of sonication prosthetic fluid PCR for diagnosing periprosthetic joint infection.PloS one · 2018Pooled it
- Meta-analysis of sonication fluid samples from prosthetic components for diagnosis of infection after total joint arthroplasty.Journal of clinical microbiology · 2014Pooled it
- Preoperative aspiration culture for preoperative diagnosis of infection in total hip or knee arthroplasty.Journal of clinical microbiology · 2013Pooled it
- PCR-based diagnosis of prosthetic joint infection.Journal of clinical microbiology · 2013Pooled it
- The boundary between microbial detection and implant-related infection: a structured narrative review of analytical credibility, biological persistence, host response, and clinical causality.Archives of orthopaedic and trauma surgery · 2026Review
- Currently applied sonication protocols for the detection of implant-associated infections in orthopaedics: a scoping review.Journal of clinical microbiology · 2026Article
- Synovial Periprosthetic Infection Markers Show High Variability in Different Clinical and Microbiological Settings.Journal of clinical medicine · 2025Article
- Article
- [Arthritis and osteomyelitis in childhood and adolescence-Bacterial and nonbacterial].Zeitschrift fur Rheumatologie · 2025Review
- Clinical characteristics of culture-negative periprosthetic joint infections: findings from an international periprosthetic joint infection registry.Journal of bone and joint infection · 2025Article
- Clinical evaluation of a multiplex PCR-based test for joint infection: a prospective diagnostic accuracy study of forty-nine patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Enhancing Pathogen Detection in Implant-Related Infections through Chemical Antibiofilm Strategies: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2024Review
- Diagnostic Performance of a Molecular Assay in Synovial Fluid Targeting Dominant Prosthetic Joint Infection Pathogens.Microorganisms · 2024Article
- Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections.Clinical microbiology reviews · 2024Review
- Evaluation of Sonicate Fluid Culture Cutoff Points for Periprosthetic Joint Infection Diagnosis.Open forum infectious diseases · 2024Article
- Article
- Association of coagulase-negative staphylococci with orthopedic infections detected by in-house multiplex real-time PCR.Frontiers in microbiology · 2024Article
- Periprosthetic Joint Infection Diagnosis: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
We previously showed that culture of samples obtained by prosthesis vortexing and sonication was more sensitive than tissue culture for prosthetic joint infection (PJI) diagnosis. Despite improved sensitivity, culture-negative cases remained; furthermore, culture has a long turnaround time. We designed a genus-/group-specific rapid PCR assay panel targeting PJI bacteria and applied it to samples obtained by vortexing and sonicating explanted hip and knee prostheses, and we compared the results to those with sonicate fluid and periprosthetic tissue culture obtained at revision or resection arthroplasty. We studied 434 subjects with knee (n = 272) or hip (n = 162) prostheses; using a standardized definition, 144 had PJI. Sensitivities of tissue culture, of sonicate fluid culture, and of PCR were 70.1, 72.9, and 77.1%, respectively. Specificities were 97.9, 98.3, and 97.9%, respectively. Sonicate fluid PCR was more sensitive than tissue culture (P = 0.04). PCR of prosthesis sonication samples is more sensitive than tissue culture for the microbiologic diagnosis of prosthetic hip and knee infection and provides same-day PJI diagnosis with definition of microbiology. The high assay specificity suggests that typical PJI bacteria may not cause aseptic implant failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.