ArticleJournal of clinical microbiology2013
Rapid and reliable identification of Staphylococcus aureus capsular serotypes by means of artificial neural network-assisted Fourier transform infrared spectroscopy.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Antimicrobial Ionic Liquids: Ante-Mortem Mechanisms of Pathogenic EPEC and MRSA Examined by FTIR Spectroscopy.International journal of molecular sciences · 2024Article
- Fourier-transform infrared spectroscopy for typing of vancomycin-resistantMicrobiology spectrum · 2023Article
- Article
- Prevalence of the SigB-Deficient Phenotype among ClinicalAntibiotics (Basel, Switzerland) · 2023Article
- A multi-center validation study on the discrimination ofFrontiers in microbiology · 2023Article
- First isolation of Arcanobacterium pinnipediorum from a grey seal pup (Halichoerus grypus) in the UK.Folia microbiologica · 2022Article
- Within-Host Adaptation ofInternational journal of molecular sciences · 2021Article
- Article
- Attenuated total reflection: Fourier transform infrared spectroscopy for detection of heterogeneous vancomycin-intermediate Staphylococcus aureus.World journal of microbiology & biotechnology · 2020Article
- Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.Antibiotics (Basel, Switzerland) · 2019Article
- Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic activity and biofilm formation.Scientific reports · 2019Article
- Fourier transform infrared spectroscopy: unlocking fundamentals and prospects for bacterial strain typing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Detection and Identification ofFrontiers in microbiology · 2019Article
- Fourier-Transform Infrared (FTIR) Spectroscopy for Typing of ClinicalFrontiers in microbiology · 2019Article
- Identification and Quantification of Texture Soy Protein in A Mixture with Beef Meat Using ATR-FTIR Spectroscopy in Combination with Chemometric Methods.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Distinct phenotypic traits of Staphylococcus aureus are associated with persistent, contagious bovine intramammary infections.Scientific reports · 2018Article
- Blood hyperviscosity identification with reflective spectroscopy of tongue tip based on principal component analysis combining artificial neural network.Biomedical engineering online · 2018Article
- Analysis of Staphylococcus aureus wall teichoic acid glycoepitopes by Fourier Transform Infrared Spectroscopy provides novel insights into the staphylococcal glycocode.Scientific reports · 2018Article
- Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae.BMC veterinary research · 2017Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus capsular polysaccharides (CP) are important virulence factors and represent putative targets for vaccine development. Therefore, the purpose of this study was to develop a high-throughput method to identify and discriminate the clinically important S. aureus capsular serotypes 5, 8, and NT (nontypeable). A comprehensive set of clinical isolates derived from different origins and control strains, representative for each serotype, were used to establish a CP typing system based on Fourier transform infrared (FTIR) spectroscopy and chemometric techniques. By combining FTIR spectroscopy with artificial neuronal network (ANN) analysis, a system was successfully established, allowing a rapid identification and discrimination of all three serotypes. The overall accuracy of the ANN-assisted FTIR spectroscopy CP typing system was 96.7% for the internal validation and 98.2% for the external validation. One isolate in the internal validation and one isolate in the external validation failed in the classification procedure, but none of the isolates was incorrectly classified. The present study demonstrates that ANN-assisted FTIR spectroscopy allows a rapid and reliable discrimination of S. aureus capsular serotypes. It is suitable for diagnostic as well as large-scale epidemiologic surveillance of S. aureus capsule expression and provides useful information with respect to chronicity of infection.
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