ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Genomic imprinting effects of the X chromosome on brain morphology.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis.Neuropsychology review · 2018Pooled it
- Review
- Review
- Relationship between X chromosome mosaicism, neuroanatomy and cognitive performance in females.bioRxiv : the preprint server for biology · 2026Article
- Intergenerational neuroimaging's present and future: Considering sex as a biological variable to enhance knowledge of brain development through parent-offspring similarity.Developmental cognitive neuroscience · 2025Review
- Deep Screening for X Chromosome Parent-of-Origin Effects on Neurobehavioral and Neuroanatomical Phenotypes in 47,XXY Klinefelter Syndrome.Biological psychiatry global open science · 2024Article
- Syndrome-Specific Neuroanatomical Phenotypes in Girls With Turner and Noonan Syndromes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Adolescent brain development in girls with Turner syndrome.Human brain mapping · 2023Article
- Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain.Frontiers in cell and developmental biology · 2023Review
- PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders.Cell & bioscience · 2022Article
- Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome.Journal of autism and developmental disorders · 2022Observational
- Contributions of Sex Chromosomes and Gonadal Hormones to the Male Bias in a Maternal Antibody-Induced Model of Autism Spectrum Disorder.Frontiers in neurology · 2021Article
- Sex differences in cancer mechanisms.Biology of sex differences · 2020Review
- Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting.Biological psychiatry · 2020Article
- Sex differences in amygdala shape: Insights from Turner syndrome.Human brain mapping · 2016Article
- Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies.Brain structure & function · 2015Article
- Preliminary Evidence for Aortopathy and an X-Linked Parent-of-Origin Effect on Aortic Valve Malformation in a Mouse Model of Turner Syndrome.Journal of cardiovascular development and disease · 2015Article
- Mapping the stability of human brain asymmetry across five sex-chromosome aneuploidies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Brain and behavior in 48, XXYY syndrome.NeuroImage. Clinical · 2015Article
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8 authors.
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Abstract
There is increasing evidence that genomic imprinting, a process by which certain genes are expressed in a parent-of-origin-specific manner, can influence neurogenetic and psychiatric manifestations. While some data suggest possible imprinting effects of the X chromosome on physical and cognitive characteristics in humans, there is no compelling evidence that X-linked imprinting affects brain morphology. To address this issue, we investigated regional cortical volume, thickness, and surface area in 27 healthy controls and 40 prepubescent girls with Turner syndrome (TS), a condition caused by the absence of one X chromosome. Of the young girls with TS, 23 inherited their X chromosome from their mother (X(m)) and 17 from their father (X(p)). Our results confirm the existence of significant differences in brain morphology between girls with TS and controls, and reveal the presence of a putative imprinting effect among the TS groups: girls with X(p) demonstrated thicker cortex than those with X(m) in the temporal regions bilaterally, while X(m) individuals showed bilateral enlargement of gray matter volume in the superior frontal regions compared with X(p). These data suggest the existence of imprinting effects of the X chromosome that influence both cortical thickness and volume during early brain development, and help to explain variability in cognitive and behavioral manifestations of TS with regard to the parental origin of the X chromosome.
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