ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Imbalance between excitation and inhibition in the somatosensory cortex produces postadaptation facilitation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Sensory adaptation supports flexible evidence accumulation during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Surround motion modulates the encoding properties of primate retinal ganglion cells.Cell reports · 2026Article
- In Vivo Analysis of Medial Perforant Path-Evoked Excitation and Inhibition in Dentate Granule Cells.eNeuro · 2025Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Dynamic fading memory and expectancy effects in the monkey primary visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.Journal of neuroinflammation · 2023Article
- Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex.Frontiers in cellular neuroscience · 2023Article
- Sensory adaptation mediates efficient and unambiguous encoding of natural stimuli by vestibular thalamocortical pathways.Nature communications · 2022Article
- Article
- Autonomic and Electrophysiological Evidence for Reduced Auditory Habituation in Autism.Journal of autism and developmental disorders · 2021Article
- Rapid Cortical Adaptation and the Role of Thalamic Synchrony during Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Sensory Adaptation in the Whisker-Mediated Tactile System: Physiology, Theory, and Function.Frontiers in neuroscience · 2021Review
- Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Is It Possible to Improve Working Memory With Prefrontal tDCS? Bridging Currents to Working Memory Models.Frontiers in psychology · 2020Article
- Multiple Timescales Account for Adaptive Responses across Sensory Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neural sensitization improves encoding fidelity in the primate retina.Nature communications · 2019Article
- Adaptation of Inhibition Mediates Retinal Sensitization.Current biology : CB · 2019Article
- Imaging localized neuronal activity at fast time scales through biomechanics.Science advances · 2019Article
- Short-Term Synaptic Plasticity as a Mechanism for Sensory Timing.Trends in neurosciences · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptation is typically associated with attenuation of the neuronal response during sustained or repetitive sensory stimulation, followed by a gradual recovery of the response to its baseline level thereafter. Here, we examined the process of recovery from sensory adaptation in layer IV cells of the rat barrel cortex using in vivo intracellular recordings. Surprisingly, in approximately one-third of the cells, the response to a test stimulus delivered a few hundred milliseconds after the adapting stimulation was significantly facilitated. Recordings under different holding potentials revealed that the enhanced response was the result of an imbalance between excitation and inhibition, where a faster recovery of excitation compared with inhibition facilitated the response. Hence, our data provide the first mechanistic explanation of sensory facilitation after adaptation and suggest that adaptation increases the sensitivity of cortical neurons to sensory stimulation by altering the balance between excitation and inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.