ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The long-term structural plasticity of cerebellar parallel fiber axons and its modulation by motor learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation.Science advances · 2025Article
- Adaptations in the Structure and Function of the Cerebellum in Basketball Athletes.Brain sciences · 2025Article
- The epithelial NaCell reports · 2023Article
- C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity.Molecular brain · 2023Article
- Synaptic modifications in learning and memory - A dendritic spine story.Seminars in cell & developmental biology · 2022Review
- Shedding light on learning and memory: optical interrogation of the synaptic circuitry.Current opinion in neurobiology · 2021Review
- B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Insights into cerebellar development and connectivity.Neuroscience letters · 2019Review
- Circuit changes in motor cortex during motor skill learning.Neuroscience · 2018Review
- Cerebellar sub-divisions differ in exercise-induced plasticity of noradrenergic axons and in their association with resilience to activity-based anorexia.Brain structure & function · 2017Article
- Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs.Trends in neurosciences · 2016Review
- Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum.Nature communications · 2016Article
- Chronic imaging of movement-related Purkinje cell calcium activity in awake behaving mice.Journal of neurophysiology · 2016Article
- Long-term in vivo time-lapse imaging of synapse development and plasticity in the cerebellum.Journal of neurophysiology · 2014Article
- Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome.eNeuroArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Presynaptic axonal varicosities, like postsynaptic spines, are dynamically added and eliminated even in mature neuronal circuitry. To study the role of this axonal structural plasticity in behavioral learning, we performed two-photon in vivo imaging of cerebellar parallel fibers (PFs) in adult mice. PFs make excitatory synapses on Purkinje cells (PCs) in the cerebellar cortex, and long-term potentiation and depression at PF-PC synapses are thought to play crucial roles in cerebellar-dependent learning. Time-lapse vital imaging of PFs revealed that, under a control condition (no behavioral training), ∼10% of PF varicosities appeared and disappeared over a period of 2 weeks without changing the total number of varicosities. The fraction of dynamic PF varicosities significantly diminished during training on an acrobatic motor skill learning task, largely because of reduced addition of new varicosities. Thus, this form of motor learning was associated with greater structural stability of PFs and a slight decrease in the total number of varicosities. Together with prior findings that the number of PF-PC synapses increases during similar training, our results suggest that acrobatic motor skill learning involves a reduction of some PF inputs and a strengthening of others, probably via the conversion of some preexisting PF varicosities into multisynaptic terminals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.