ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Characterizing the normal range of myocardial blood flow with ⁸²rubidium and ¹³N-ammonia PET imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantification of Myocardial Blood Flow by Positron Emission Tomography in Healthy Volunteers
Quantification of Myocardial Blood Flow by 3D Positron Emission Tomography With High and Low Rate Rb82 Infusion Profiles
Who cites it
25 citing papers in PubMed.
- Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
- Feasibility and operator variability of myocardial blood flow and reserve measurements with ⁹⁹mTc-sestamibi quantitative dynamic SPECT/CT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Measuring myocardial blood flow using dynamic myocardial perfusion SPECT: artifacts and pitfalls.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Development of a dynamic myocardial perfusion phantom model for tracer kinetic measurements.EJNMMI physics · 2022Article
- Internal validation of myocardial flow reserve PET imaging using stress/rest myocardial activity ratios with Rb-82 and N-13-ammonia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Observational
- Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: Correlation and accuracy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Reliability and Reproducibility of Absolute Myocardial Blood Flow: Does It Depend on the PET/CT Technology, the Vasodilator, and/or the Software?Current cardiology reports · 2021Review
- Quantitative blood flow evaluation of vasodilation-stress compared with dobutamine-stress in patients with end-stage liver disease usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Multiparametric CardiacIEEE transactions on radiation and plasma medical sciences · 2020Article
- Comparison of two dipyridamole infusion protocols for myocardial perfusion imaging in subjects with low likelihood of significant obstructive coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Simplified quantification of PET myocardial blood flow: The need for technical standardization.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Simplified quantification ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Impaired myocardial perfusion is associated with increasing end-systolic- and end-diastolic volumes in patients with non-ischemic systolic heart failure: a cross-sectional study using Rubidium-82 PET/CT.BMC cardiovascular disorders · 2019Article
- First validation of myocardial flow reserve assessed by dynamicEuropean journal of nuclear medicine and molecular imaging · 2018Article
- Myocardial perfusion in patients with non-ischaemic systolic heart failure and type 2 diabetes: a cross-sectional study using Rubidium-82 PET/CT.The international journal of cardiovascular imaging · 2018Article
- Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Optimizing quantitative myocardial perfusion by positron emission tomography for guiding CAD management.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Time-frame sampling forJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Quantification of myocardial blood flow with (82)Rb: Validation with (15)O-water using time-of-flight and point-spread-function modeling.EJNMMI research · 2016Article
- Quantitative Coronary Physiology for Clinical Management: the Imaging Standard.Current cardiology reports · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
backgroundDiagnosis of coronary disease and microvascular dysfunction may be improved by comparing myocardial perfusion scans with a database defining the lower limit of normal myocardial blood flow and flow reserve (MFR). To maximize disease detection sensitivity, a small normal range is desirable. Both (13)N-ammonia and (82)Rb tracers are used to quantify blood flow and MFR using positron emission tomography (PET). The goal of this study was to investigate the trade-off between noise and accuracy in both (82)Rb and (13)N-ammonia normal databases formed using a net retention model.
methodsFourteen subjects with <5% risk of CAD underwent rest and stress (82)Rb and (13)N-ammonia dynamic PET imaging in a randomized order within 2 weeks. Myocardial blood flow was quantified using a one-compartment model for (82)Rb, and a two-compartment model for (13)N-ammonia. A simplified model was used to estimate tracer retention, with tracer-specific net extraction functions derived to obtain flow estimates.
resultsNormal variability of retention reserve was equivalent for both tracers (±15% globally, ±16% regionally) and was lower in comparison to compartment model results (P < .05). The two-compartment model for (13)N-ammonia had the smallest normal range of global blood flow resulting in a lower limit of normal MFR = 2.2 (mean - 2 SD).
conclusionThese results suggest that the retention model may have higher sensitivity for detection and localization of abnormal flow and MFR using (82)Rb and (13)N-ammonia, whereas the (13)N-ammonia two-compartment model has higher precision for absolute flow quantification.
Indexed as
Identifiers
23657833What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.