ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- The Stop Signal Task for Measuring Behavioral Inhibition in Mice With Increased Sensitivity and High-Throughput Operation.Frontiers in behavioral neuroscience · 2021Article
- The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task.Brain research · 2020Article
- Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition.Human molecular genetics · 2019Article
- Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Feeding behaviour, risk-sensitivity and response control: effects of 5-HTPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Impulsive Choice in Mice Lacking Paternal Expression ofGenetics · 2018Article
- Cross-species studies of cognition relevant to drug discovery: a translational approach.British journal of pharmacology · 2017Review
- Gambling disorder: an integrative review of animal and human studies.Annals of the New York Academy of Sciences · 2017Review
- Attention deficit hyperactivity disorder (ADHD) in phenotypically similar neurogenetic conditions: Turner syndrome and the RASopathies.Journal of neurodevelopmental disorders · 2017Review
- Methylphenidate has nonlinear dose effects on cued response inhibition in adults but not adolescents.Brain research · 2017Article
- Developing treatments for cognitive deficits in schizophrenia: the challenge of translation.Journal of psychopharmacology (Oxford, England) · 2015Review
- Recent Translational Findings on Impulsivity in Relation to Drug Abuse.Current addiction reports · 2014Article
- The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison with drugs used in ADHD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Animal model of methylphenidate's long-term memory-enhancing effects.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal models are making an increasing contribution to our understanding of the psychology and brain mechanisms underlying behavioral inhibition and impulsivity. The aim here was to develop, for the first time, a mouse analog of the stop-signal reaction time task with high translational validity in order to be able to exploit this species in genetic and molecular investigations of impulsive behaviors. Cohorts of mice were trained to nose-poke to presentations of visual stimuli. Control of responding was manipulated by altering the onset of an auditory 'stop-signal' during the go response. The anticipated systematic changes in action cancellation were observed as stopping was made more difficult by placing the stop-signal closer to the execution of the action. Excitotoxic lesions of medial prefrontal cortex resulted in impaired stopping, while the clinically effective drugs methylphenidate and atomoxetine enhanced stopping abilities. The specific 5-HT2C receptor antagonist SB242084 also led to enhanced response control in this task. We conclude that stop-signal reaction time task performance can be successfully modeled in mice and is sensitive to prefrontal cortex dysfunction and drug treatments in a qualitatively similar manner to humans and previous rat models. Additionally, using this model we show novel and highly discrete effects of 5-HT2C receptor antagonism that suggest manipulation of 5-HT2C receptor function may be of use in correcting maladaptive impulsive behaviors and provide further evidence for dissociable contributions of serotonergic transmission to response control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.