Evidence map›Paper›PMID 23657262›Full record

ArticleNanoscale2013

Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.

Sang-Min Lee, De-Hao Tsai, Vincent A Hackley, Martin W Brechbiel, Robert F Cook

Open access · greenAbstract read
In one paragraph

Article in Nanoscale, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sang-Min LeeMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.
De-Hao Tsai
Vincent A Hackley
Martin W Brechbiel
Robert F Cook
Material Measurement Laboratory · USNational Cancer Institute · USNational Institutes of Health · US

Funding

Metal Chelate Conjugated Dendrimer Constructs for Diagnosis and TherapyZIASC010051 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI BRECHBIEL, MARTIN W · 2009 to 2017
$4.7M
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPYZ01SC006353 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI BRECHBIEL, MARTIN W · 1996 to 2008
$1.8M
Intramural NIH HHS Z01 SC006353
6 · The paper itself

Abstract

We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.

Indexed as

Radiation, IonizingAcrylic ResinsAntineoplastic AgentsCell Line, TumorCell SurvivalCisplatinDrug CarriersGoldHumansMCF-7 CellsMetal NanoparticlesPlatinumThioctic AcidX-Ray Absorption SpectroscopyAcrylic ResinsAntineoplastic Agentscarbopol 940CisplatinDrug CarriersGoldPlatinumThioctic Acid

Identifiers

PMID23657262
PMCPMC6957245
OpenAlexW2001881825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.