ArticleScientific reports2013
Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Alternative nucleic acid structures in microbial biology: regulatory functions and antimicrobial opportunities.Frontiers in cellular and infection microbiology · 2026Review
- ssG4-seq for global profiling of strand-specific G-quadruplex structures in mammalian genomes.Nature communications · 2025Article
- A cry for kelp: Evidence for polyphenolic inhibition of Oxford Nanopore sequencing of brown algae.Journal of phycology · 2024Article
- Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase.Nature communications · 2023Article
- Never Cared for What They Do: High Structural Stability of Guanine-Quadruplexes in the Presence of Strand-Break Damage.Molecules (Basel, Switzerland) · 2022Article
- G-quadruplexes: a promising target for cancer therapy.Molecular cancer · 2021Review
- Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.Nucleic acids research · 2021Article
- Genome-Wide Discovery of G-Quadruplexes in Wheat: Distribution and Putative Functional Roles.G3 (Bethesda, Md.) · 2020Article
- Modulation of DNA structure formation using small molecules.Biochimica et biophysica acta. Molecular cell research · 2019Review
- Oxidative Stress: Role and Response of Short Guanine Tracts at Genomic Locations.International journal of molecular sciences · 2019Review
- Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry.Molecules (Basel, Switzerland) · 2019Article
- Synthesis, characterization and biological evaluation of six highly cytotoxic ruthenium(ii) complexes with 4'-substituted-2,2':6',2''-terpyridine.MedChemComm · 2018Article
- Small-Molecule-Based Self-Assembled Ligands for G-Quadruplex DNA Surface Recognition.ACS omega · 2017Article
- Article
- On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids.Journal of nucleic acids · 2017Review
- Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor Activity.Scientific reports · 2016Article
- QuadBase2: web server for multiplexed guanine quadruplex mining and visualization.Nucleic acids research · 2016Article
- Structural revisions of small molecules reported to cross-link G-quadruplex DNA in vivo reveal a repetitive assignment error in the literature.Scientific reports · 2016Article
- A bouquet of DNA structures: Emerging diversity.Biochemistry and biophysics reports · 2016Review
- Extended molecular dynamics of a c-kit promoter quadruplex.Nucleic acids research · 2015Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Existence of G-quadruplex DNA in vivo always attract widespread interest in the field of biology and biological chemistry. We reported our findings for the existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Probes for selective G-quadruplex cross-linking was designed and synthesized that show high selectivity for G-quadruplex cross-linking. Further biological studies demonstrated its good inhibition activity against murine melanoma cells. To further investigate if G-quadruplex DNA was formed in vivo and as the target, a derivative was synthesized and pull-down process toward chromosome DNAs combined with circular dichroism and high throughput deep sequencing were performed. Several simulated intracellular conditions, including X. laevis oocytes, Ficoll 70 and PEG, was used to investigate the compound's pure cross-linking ability upon preformed G-quadruplex. Thus, as a potent G-quadruplex cross-linking agent, our strategy provided both valuable evidence of G-quadruplex structures in vivo and intense potential in anti-cancer therapy.
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