ArticleProceedings of the National Academy of Sciences of the United States of America2013
The age-specific force of natural selection and biodemographic walls of death.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Evolution of Senescence by Damage Accumulation That Accelerates With Age Throughout an Organism's Lifespan.Ecology and evolution · 2026Article
- How and why does aging occur? Updating evolutionary theory to meet a new era of data.Evolution, medicine, and public health · 2026Article
- Senescence evolution under the catastrophic accumulation of deleterious mutations.Evolution letters · 2024Article
- Article
- The importance of elders: Extending Hamilton's force of selection to include intergenerational transfers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a.Bone research · 2022Article
- The selection force weakens with age because ageing evolves and not vice versa.Nature communications · 2022Article
- Demographic perspectives on the rise of longevity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases.Nature ecology & evolution · 2021Article
- Deleterious mutations show increasing negative effects with age in Drosophila melanogaster.BMC biology · 2020Article
- Longevity and the drift barrier: Bridging the gap between Medawar and Hamilton.Evolution letters · 2020Article
- Evolution of ageing as a tangle of trade-offs: energy versus function.Proceedings. Biological sciences · 2019Article
- Pleiotropic Effects of mTOR and Autophagy During Development and Aging.Frontiers in cell and developmental biology · 2019Review
- Antagonistically pleiotropic allele increases lifespan and late-life reproduction at the cost of early-life reproduction and individual fitness.Proceedings. Biological sciences · 2017Article
- Discrete Barker Frailty and Warped Mortality Dynamics at Older Ages.Demography · 2017Article
- Insights into mortality patterns and causes of death through a process point of view model.Biogerontology · 2017Review
- Evolution of maternal effect senescence.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Constant mortality and fertility over age in Hydra.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Measuring selective constraint on fertility in human life histories.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Genetics, lifestyle and longevity: Lessons from centenarians.Applied & translational genomics · 2015Review
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Abstract
W. D. Hamilton's celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton's setting the full nonlinear demographic model for mutation accumulation recently developed by Evans, Steinsaltz, and Wachter, we find surprising differences. Nonlinear interactions cause the collapse of Hamilton-style predictions in the most commonly studied case, refine predictions in other cases, and allow walls of death at ages before the end of reproduction. Haldane's principle for genetic load has an exact but unfamiliar generalization.
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