ArticlePlant physiology2013
Deciphering herbivory-induced gene-to-metabolite dynamics in Nicotiana attenuata tissues using a multifactorial approach.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Heat stress reprograms herbivory-induced defense responses in potato plants.BMC plant biology · 2024Article
- Article
- Moth oviposition shapes the species-specific transcriptional and phytohormonal response of Nicotiana attenuata to larval feeding.Scientific reports · 2018Article
- Argonaute 8 (AGO8) Mediates the Elicitation of Direct Defenses against Herbivory.Plant physiology · 2017Article
- Nicotiana attenuata Data Hub (NaDH): an integrative platform for exploring genomic, transcriptomic and metabolomic data in wild tobacco.BMC genomics · 2017Article
- Illuminating a plant's tissue-specific metabolic diversity using computational metabolomics and information theory.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Evolution of herbivore-induced early defense signaling was shaped by genome-wide duplications ineLife · 2016Article
- Oral secretions from Mythimna separata insects specifically induce defence responses in maize as revealed by high-dimensional biological data.Plant, cell & environment · 2016Article
- Beyond the Canon: Within-Plant and Population-Level Heterogeneity in Jasmonate Signaling Engaged by Plant-Insect Interactions.Plants (Basel, Switzerland) · 2016Review
- Analysis of key genes of jasmonic acid mediated signal pathway for defense against insect damages by comparative transcriptome sequencing.Scientific reports · 2015Article
- Navigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Revealing insect herbivory-induced phenolamide metabolism: from single genes to metabolic network plasticity analysis.The Plant journal : for cell and molecular biology · 2014Review
- The roots of plant defenses: integrative multivariate analyses uncover dynamic behaviors of gene and metabolic networks of roots elicited by leaf herbivory.The Plant journal : for cell and molecular biology · 2014Article
- An integrative statistical method to explore herbivory-specific responses in plants.Plant signaling & behavior · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In response to biotic stresses, such as herbivore attack, plants reorganize their transcriptomes and reconfigure their physiologies not only in attacked tissues but throughout the plant. These whole-organismic reconfigurations are coordinated by a poorly understood network of signal transduction cascades. To explore tissue-based interdependencies in the resistance of Nicotiana attenuata to insect attack, we conducted time-series transcriptome and metabolome profiling of herbivory-elicited source leaves and unelicited sink leaves and roots. To probe the multidimensionality of these molecular responses, we designed a novel approach of combining an extended self-organizing maps-based dimensionality reduction method with bootstrap-based nonparametric analysis of variance models to identify the onset and context of signaling and metabolic pathway activations. We illustrate the value of this analysis by revisiting dynamic changes in the expression of regulatory and structural genes of the oxylipin pathway and by studying nonlinearities in gene-metabolite associations involved in the acyclic diterpene glucoside pathway after selectively extracting modules based on their dynamic response patterns. This novel dimensionality reduction approach is broadly applicable to capture the dynamic rewiring of gene and metabolite networks in experimental design with multiple factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.