ArticleMolecular plant-microbe interactions : MPMI2013
The role of Arabidopsis heterotrimeric G-protein subunits in MLO2 function and MAMP-triggered immunity.
Article in Molecular plant-microbe interactions : MPMI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 69 citations in OpenAlex.
- Arabidopsis Heterotrimeric G Beta Variants Shape Plant Development and Modulate Responses to Endoplasmic Reticulum Stress and Salt Stress.Plant, cell & environment · 2026Article
- Review
- Heterotrimeric G Proteins in Plants: Canonical and Atypical Gα Subunits.International journal of molecular sciences · 2021Review
- The transcriptional landscape of Arabidopsis thaliana pattern-triggered immunity.Nature plants · 2021Article
- Heterotrimeric G-protein α subunit (RGA1) regulates tiller development, yield, cell wall, nitrogen response and biotic stress in rice.Scientific reports · 2021Article
- Seedling Chloroplast Responses Induced byPlant physiology · 2020Article
- Plant receptor-like kinase signaling through heterotrimeric G-proteins.Journal of experimental botany · 2020Review
- Arabidopsis mlo3 mutant plants exhibit spontaneous callose deposition and signs of early leaf senescence.Plant molecular biology · 2019Article
- Genome-wide analysis of the cotton G-coupled receptor proteins (GPCR) and functional analysis of GTOM1, a novel cotton GPCR gene under drought and cold stress.BMC genomics · 2019Article
- The Role of Gβ Protein in Controlling Cell Expansion via Potential Interaction with Lipid Metabolic Pathways.Plant physiology · 2019Article
- Inter-relationships between the heterotrimeric Gβ subunit AGB1, the receptor-like kinase FERONIA, and RALF1 in salinity response.Plant, cell & environment · 2018Article
- Transcriptional responses of soybean roots to colonization with the root endophytic fungus Piriformospora indica reveals altered phenylpropanoid and secondary metabolism.Scientific reports · 2018Article
- The G ProteinPlant physiology · 2018Article
- Alteration of cell wall xylan acetylation triggers defense responses that counterbalance the immune deficiencies of plants impaired in the β-subunit of the heterotrimeric G-protein.The Plant journal : for cell and molecular biology · 2017Article
- Intracellular Ca2+ is important for flagellin-triggered defense in Arabidopsis and involves inositol polyphosphate signaling.Journal of experimental botany · 2017Article
- Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition.The Plant cell · 2017Review
- Ligand-induced dynamics of heterotrimeric G protein-coupled receptor-like kinase complexes.PloS one · 2017Article
- Regulation of plant reactive oxygen species (ROS) in stress responses: learning from AtRBOHD.Plant cell reports · 2016Review
- Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor.eLife · 2016Article
- Comparative analysis of genome-wide Mlo gene family in Cajanus cajan and Phaseolus vulgaris.Genetica · 2016Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Heterotrimeric G-proteins, composed of Gα, Gβ, and Gγ subunits, regulate many fundamental processes in plants. In animals, ligand binding to seven transmembrane (7TM) cell surface receptors designated G-protein coupled receptors (GPCR) leads to heterotrimeric G-protein activation. Because the plant G-protein complex is constitutively active, the exact role of plant 7TM proteins in this process is unclear. Members of the mildew resistance locus O (MLO) family represent the best-characterized 7TM plant proteins. Although genetic ablation of either MLO2 or G-proteins alters susceptibility to pathogens in Arabidopsis thaliana, it is unknown whether G-proteins directly couple signaling through MLO2. Here, we exploited two well-documented phenotypes of mlo2 mutants, broad-spectrum powdery mildew resistance and spontaneous callose deposition in leaf mesophyll cells, to assess the relationship of MLO2 proteins to the G-protein complex. Although our data reveal modulation of antifungal defense responses by Gβ and Gγ subunits and a role for the Gγ1 subunit in mlo2-conditioned callose deposition, our findings overall are inconsistent with a role of MLO2 as a canonical GPCR. We discovered that mutants lacking the Gβ subunit show delayed accumulation of a subset of defense-associated genes following exposure to the microbe-associated molecular pattern flg22. Moreover, Gβ mutants were found to be hypersusceptible to spray inoculation with the bacterial pathogen Pseudomonas syringae.
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