ReviewComputational and mathematical methods in medicine2013
A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading.
Review in Computational and mathematical methods in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Shear Strain Stiffening in Cartilage is Governed by a Mechanical Phase Transition.bioRxiv : the preprint server for biology · 2026Article
- Interstitial Fluid Load Support in Human Articular Cartilage: Effects of Degeneration, Loading, and Material Properties via Combined Experimental Testing and Computational Modeling.Annals of biomedical engineering · 2026Article
- The Influence of the Chondrocyte Microenvironment on Multiscale Articular Cartilage Mechanics: A Computational Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Role of collagen VI and IX in mechanotransduction in the cartilage microenvironments: A multiscale in silico examination.Journal of orthopaedic translation · 2026Article
- Exploring mechanisms governing cartilage interstitial fluid load support in lubrication through experimental and computational analysis.Scientific reports · 2026Article
- Nonlinear Stress-Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone-Cartilage Unit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study.Annals of biomedical engineering · 2024Article
- Depth-Dependent Strain Model (1D) for Anisotropic Fibrils in Articular Cartilage.Materials (Basel, Switzerland) · 2024Article
- Contributions of cell behavior to geometric order in embryonic cartilage.PLoS computational biology · 2023Article
- Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage.Acta biomaterialia · 2021Article
- Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage.Annals of biomedical engineering · 2021Article
- AnFrontiers in bioengineering and biotechnology · 2021Article
- Structure-Function Relationships of Healthy and Osteoarthritic Human Tibial Cartilage: Experimental and Numerical Investigation.Annals of biomedical engineering · 2020Article
- Use of Computational Modeling to Study Joint Degeneration: A Review.Frontiers in bioengineering and biotechnology · 2020Review
- Computational Modeling of Developing Cartilage Using Experimentally Derived Geometries and Compressive Moduli.Journal of biomechanical engineering · 2019Article
- Simulation of surface strain in tibiofemoral cartilage during walking for the prediction of collagen fiber orientation.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2019Article
- Influence of the pericellular and extracellular matrix structural properties on chondrocyte mechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2018Review
- Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues.ACS biomaterials science & engineering · 2017Review
- Determining Tension-Compression Nonlinear Mechanical Properties of Articular Cartilage from Indentation Testing.Annals of biomedical engineering · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e.g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and progression of OA, local tissue and cell stresses and strains in cartilage need to be characterized. This is extremely challenging with the presently available experimental techniques and therefore computational modeling is required. Modern models of articular cartilage are inhomogeneous and anisotropic, and they include many aspects of the real tissue structure and composition. In this paper, we provide an overview of the computational applications that have been developed for modeling the mechanics of articular cartilage at the tissue and cellular level. We concentrate on the use of fibril-reinforced models of cartilage. Furthermore, we introduce practical considerations for modeling applications, including also experimental tests that can be combined with the modeling approach. At the end, we discuss the prospects for patient-specific models when aiming to use finite element modeling analysis and evaluation of articular cartilage function, cellular responses, failure points, OA progression, and rehabilitation.
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Registered trials
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