ArticleFrontiers in genetics2013
Neuronal inputs and outputs of aging and longevity.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells inScience advances · 2025Article
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- Glial-derived mitochondrial signals affect neuronal proteostasis and aging.Science advances · 2023Article
- Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory EvolvedInternational journal of molecular sciences · 2022Article
- The pond snail Lymnaea stagnalis.EvoDevo · 2020Review
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- Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet inEvolution letters · 2019Article
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- Reduced Neuronal Transcription ofFrontiers in genetics · 2018Article
- The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan.PLoS genetics · 2017Article
- The odor of a plant metabolite affects life history traits in dietary restricted adult olive flies.Scientific reports · 2016Article
- Aging and brain rejuvenation as systemic events.Journal of neurochemistry · 2015Review
- Drosophila nervous system as a target of aging and anti-aging interventions.Frontiers in genetics · 2015Article
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- Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs.Frontiers in genetics · 2014Article
- Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment.Frontiers in genetics · 2014Review
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- Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons.Frontiers in genetics · 2014Article
- The role of the nervous system in aging and longevity.Frontiers in genetics · 2013Article
- TRP ion channels in thermosensation, thermoregulation and metabolism.Temperature (Austin, Tex.)Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An animal's survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system. Here we highlight different aspects of the neuronal inputs and outputs of pathways that affect aging and longevity. Accordingly, we discuss how sensory inputs influence homeostasis and lifespan through the modulation of different types of neuronal signals, which reflects the complexity of the environmental cues that affect physiology. We also describe feedback, compensatory, and feed-forward mechanisms in these longevity-modulating pathways that are necessary for homeostasis. Finally, we consider the temporal requirements for these neuronal processes and the potential role of natural genetic variation in shaping the neurobiology of aging.
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