ArticleFrontiers in neural circuits2013
Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 90 citations in OpenAlex.
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Gamma-Aminobutyric Acid (GABA) as a Dietary Strategy for Enhancing Temperature Stress Resilience in Aquaculture Species.International journal of molecular sciences · 2025Review
- Automated Behavioral Profiling Using Neural Networks Reveals Differences in Stress-Like Behavior Between Cave and Surface-Dwelling Astyanax mexicanus.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Melanocyte-dependent macrophage redistribution enhances skin immunity upon acute stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Zebrafish as a Model Organism for Post-Traumatic Stress Disorder: Insights into Stress Mechanisms and Behavioral Assays.Biology · 2025Review
- Early-life challenge enhances cortisol regulation in zebrafish larvae.Biology open · 2024Article
- Cortisol dynamics and GR-dependent feedback regulation in zebrafish larvae exposed to repeated stress.Biology open · 2024Article
- All-optical presynaptic plasticity induction by photoactivated adenylyl cyclase targeted to axon terminals.Cell reports methods · 2024Article
- Altered glucocorticoid reactivity and behavioral phenotype in rx3-/- larval zebrafish.Frontiers in endocrinology · 2023Article
- Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health.Frontiers in molecular neuroscience · 2022Review
- Optogenetics for light control of biological systems.Nature reviews. Methods primers · 2022Article
- The Effects of Early Life Stress on the Brain and Behaviour: Insights From Zebrafish Models.Frontiers in cell and developmental biology · 2021Review
- Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood.BMC research notes · 2020Article
- Differences in stress reactivity between zebrafish with alternative stress coping styles.Royal Society open science · 2019Article
- Novel zebrafish behavioral assay to identify modifiers of the rapid, nongenomic stress response.Genes, brain, and behavior · 2019Article
- Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish.Communications biology · 2019Article
- Potassium channel-based optogenetic silencing.Nature communications · 2018Article
- Performance on innate behaviour during early development as a function of stress level.Scientific reports · 2017Article
- Cellular Mechanisms of Cortisol-Induced Changes in Mauthner-Cell Excitability in the Startle Circuit of Goldfish.Frontiers in neural circuits · 2017Article
- Conspecific injury raises an alarm in medaka.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stress response is a suite of physiological and behavioral processes that help to maintain or reestablish homeostasis. Central to the stress response is the hypothalamic-pituitary-adrenal (HPA) axis, as it releases crucial hormones in response to stress. Glucocorticoids (GCs) are the final effector hormones of the HPA axis, and exert a variety of actions under both basal and stress conditions. Despite their far-reaching importance for health, specific GC effects have been difficult to pin-down due to a lack of methods for selectively manipulating endogenous GC levels. Hence, in order to study stress-induced GC effects, we developed a novel optogenetic approach to selectively manipulate the rise of GCs triggered by stress. Using this approach, we could induce both transient hypercortisolic states and persistent forms of hypercortisolaemia in freely behaving larval zebrafish. Our results also established that transient hypercortisolism leads to enhanced locomotion shortly after stressor exposure. Altogether, we present a highly specific method for manipulating the gain of the stress axis with high temporal accuracy, altering endocrine and behavioral responses to stress as well as basal GC levels. Our study offers a powerful tool for the analysis of rapid (non-genomic) and delayed (genomic) GC effects on brain function and behavior, feedbacks within the stress axis and developmental programming by GCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.