ArticleMolecular syndromology2013
Diabetic embryopathy: a developmental perspective from fertilization to adulthood.
Article in Molecular syndromology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Pooled it
- A zebrafish model of nicotinamide adenine dinucleotide (NADbioRxiv : the preprint server for biology · 2025Article
- The landscape of fetus metabolism in maternal hyperglycemia.Trends in endocrinology and metabolism: TEM · 2024Article
- Pharmacological Action of Baicalin on Gestational Diabetes Mellitus in Pregnant Animals Induced by Streptozotocin via AGE-RAGE Signaling Pathway.Applied biochemistry and biotechnology · 2024Article
- NAD+ deficiency in human congenital malformations and miscarriage: A new model of pleiotropy.American journal of medical genetics. Part A · 2022Article
- Maternal diabetes negatively impacts fetal health.Open biology · 2022Review
- Skeletal malformations and growth disturbances in fetuses of mild diabetic ratsBiomedica : revista del Instituto Nacional de Salud · 2021Article
- A Glimpse at the Size of the Fetal Liver-Is It Connected with the Evolution of Gestational Diabetes?International journal of molecular sciences · 2021Review
- Neural crest metabolism: At the crossroads of development and disease.Developmental biology · 2021Review
- The Clinical Manifestations of Femoral-Facial Syndrome in an Orthopaedic Patient.Case reports in orthopedics · 2021Article
- Maternal diabetes impairs oxidative and inflammatory response in murine placenta.SpringerPlus · 2016Article
- Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Femoral-facial syndrome in an infant of a diabetic mother.BMJ case reports · 2015Article
- An approach to the identification of anomalies and etiologies in neonates with identified or suspected VACTERL (vertebral defects, anal atresia, tracheo-esophageal fistula with esophageal atresia, cardiac anomalies, renal anomalies, and limb anomalies) association.The Journal of pediatrics · 2014Review
- Thrombophilia and Recurrent Pregnancy Loss: Is heparin still the drug of choice?Sultan Qaboos University medical journal · 2014Review
- DiGeorge phenotype in the absence of 22q11 deletion - a case report.Images in paediatric cardiologyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal diabetes mellitus is one of the strongest human teratogens. Despite recent advances in the fields of clinical embryology, experimental teratology and preventive medicine, diabetes-related perturbations of the maternofetal unit maintain a considerable impact on the Healthcare System. Classic consequences of prenatal exposure to hyperglycemia encompass (early) spontaneous abortions, perinatal death and malformations. The spectrum of related malformations comprises some recurrent blastogenic monotopic patterns, i.e. holoprosencephaly, caudal dysgenesis and oculoauriculovertebral spectrum, as well as pleiotropic syndromes, i.e. femoral hypoplasia-unusual face syndrome. Despite this, most malformed fetuses display multiple blastogenic defects of the VACTERL type, whose (apparently) casual combination preclude recognizing recurrent patterns, but accurately testifies to their developmental stage at onset. With the application of developmental biology in modern medicine, the effects of diabetes on the unborn patient are expanded to include the predisposition to develop insulin resistance in adulthood. The mechanisms underlying the transgenerational correlation between maternal diabetes and proneness to adult disorders in the offspring remain unclear, and the epigenetic plasticity may represent the missing link. In this scenario, a development-driven summary of the multifaced consequences of maternal diabetes on fertility and child health may add a practical resource to the repertoire of available information on early stages of embryogenesis.
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