ArticleInternal and emergency medicine2013
Prophylaxis of venous thromboembolism in elderly patients with multimorbidity.
Article in Internal and emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Indirect Effects of the COVID-19 Pandemic on In-Hospital Outcomes among Internal Medicine Departments: A Double-Center Retrospective Study.Journal of clinical medicine · 2023Article
- Asymptomatic and symptomatic deep venous thrombosis in hospitalized acutely ill medical patients: risk factors and therapeutic implications.Thrombosis journal · 2022Article
- Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register.Internal and emergency medicine · 2018Review
- Automated versus Manual Data Extraction of the Padua Prediction Score for Venous Thromboembolism Risk in Hospitalized Older Adults.Applied clinical informatics · 2018Article
- Prophylaxis of venous thromboembolism in Internal Medicine Units: the RAMs issue.Internal and emergency medicine · 2018Article
- Observational
- Prophylaxis of venous thromboembolism in elderly patients with multi-morbidity: the REPOSI data.Internal and emergency medicine · 2015Article
- Multimorbidity and polypharmacy in the elderly: lessons from REPOSI.Internal and emergency medicine · 2014Review
- The adherence to initial processes of care in elderly patients with acute venous thromboembolism.PloS one · 2014Article
- Interventional trials with anticoagulants in acutely ill medical patients: a methodological pitfall?Internal and emergency medicine · 2013Article
- Multimorbidity and Venous Thromboembolism: Epidemiological Evidence, Pathophysiology, Prophylactic and Therapeutic Anticoagulation Efficacy, Safety, and Difficulties. A Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmacological thromboprophylaxis (TP) is known to reduce venous thromboembolism (VTE) in medical inpatients, but the criteria for risk-driven prescription, safety and impact on mortality are still debated. We analyze data on elderly patients with multimorbidities admitted in the year 2010 to the Italian internal medicine wards participating in the REPOSI registry to investigate the rate of TP during the hospital stay, and analyze the factors that are related to its prescription. Multivariate logistic regression, area under the ROC curve and CART analysis were performed to look for independent predictors of TP prescription. Association between TP and VTE, bleeding and death in hospital and during the 3-month post-discharge follow-up were explored by logistic regression and propensity score analysis. Among the 1,380 patients enrolled, 171 (15.2 %) were on TP during the hospital stay (162 on low molecular weight heparins, 9 on fondaparinux). The disability Barthel index was the main independent predictor of TP prescription. Rate of fatal and non-fatal VTE and bleeding during and after hospitalization did not differ between TP and non-TP patients. In-hospital and post-discharge mortality was significantly higher in patients on TP, that however was not an independent predictor of mortality. Among elderly medical patients there was a relatively low rate of TP, that was more frequently prescribed to patients with a higher degree of disability and who had an overall higher mortality.
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