ArticleReproductive sciences (Thousand Oaks, Calif.)2013
The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Association Between Pre-Pregnancy Body Mass Index and Labor Induction Success Rates: A Case Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- The Interplay of Uterine Health and Obesity: A Comprehensive Review.Biomedicines · 2024Review
- Maternal Body Mass Index, Myometrium Contractility and Uterotonic Receptor Expression in Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- The Pathophysiology of Labor Dystocia: Theme with Variations.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- The association between maternal body mass index and serial plasma oxytocin levels during labor.PloS one · 2023Observational
- The Role of Oxytocin in Primary Cesarean Birth Among Low-Risk Women.Journal of midwifery & women's health · 2021Article
- Use of the Robson classification to understand the increased risk of cesarean section in case of maternal obesity.BMC pregnancy and childbirth · 2020Article
- Effect of Maternal Body Mass Index on Postpartum Hemorrhage.Anesthesiology · 2018Article
- Child Maltreatment Is Associated with a Reduction of the Oxytocin Receptor in Peripheral Blood Mononuclear Cells.Frontiers in psychology · 2018Article
- Unchanged mitochondrial phenotype, but accumulation of lipids in the myometrium in obese pregnant women.The Journal of physiology · 2017Article
- Maternal body mass index and spontaneous contractility of human myometrium in pregnancy.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Parturition dysfunction in obesity: time to target the pathobiology.Reproductive biology and endocrinology : RB&E · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Obese pregnant women have higher rates of dysfunctional labor patterns, need for oxytocin augmentation, labor induction, postdates pregnancy, and cesarean delivery compared to normal weight pregnant women. We tested the hypothesis that myometrial oxytocin receptor (OXTR) gene and protein expression are affected by obesity in pregnancy. Myometrial samples were obtained at the time of cesarean delivery from the upper aspect of the uterine hysterotomy incision and processed for real-time quantitative polymerase chain reaction and Western blot. There were 63 myometrial samples available for analysis. The median body mass index (BMI) at delivery was 31.0 kg/m(2) (interquartile range, 26.0, 40.0 kg/m(2)), and the median gestational age at delivery was 38.0 weeks (interquartile range, 33.0, 39.1 weeks). The OXTR gene expression did not correlate with maternal BMI at delivery by linear regression, and the median OXTR gene expression did not differ between women with a BMI ≤ 30 kg/m(2) and those with a BMI ≥ 40 kg/m(2). The OXTR protein expression was also not affected by maternal BMI. Myometrial OXTR gene expression appears to be independent of BMI at the time of delivery. Dysfunctional labor patterns and increased oxytocin utilization seen in obese women may not be due to differences in OXTR expression, though functional studies are required.
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Registered trials
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