ArticleClinical research in cardiology : official journal of the German Cardiac Society2013
Outcomes of correcting hyponatremia in patients with myocardial infarction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Short- and long-term prognostic value of hyponatremia in patients with acute coronary syndrome: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Hyponatremia improvement is associated with a reduced risk of mortality: evidence from a meta-analysis.PloS one · 2015Pooled it
- The association of hyponatremia and clinical outcomes in patients with acute myocardial infarction: a cross-sectional study.BMC cardiovascular disorders · 2022Article
- Sodium-based osmotherapy for hyponatremia in acute decompensated heart failure.Heart failure reviews · 2022Review
- Potassium variability during hospitalization and outcomes after discharge in patients with acute myocardial infarction.Journal of geriatric cardiology : JGC · 2021Article
- Prognostic Significance of Hyponatremia in ST-elevation Myocardial Infarction/Heart Failure Patients.Cureus · 2019Review
- Sodium levels during hospitalization with acute myocardial infarction are markers of in-hospital mortality: Soroka acute myocardial infarction II (SAMI-II) project.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Observational
- Hyponatremia at discharge as a predictor of 12-month clinical outcomes in hospital survivors after acute myocardial infarction.Heart and vessels · 2017Observational
- STEMI complicated with serum sodium of 113 mmol/L from syndrome of inappropriate antidiuretic hormone secretion: How worse could it be?Journal of cardiology cases · 2014Article
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Authors and funding
10 authors.
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Abstract
backgroundHyponatremia has significant prognostic implications in patients with heart, failure. However, little data are available regarding its significance in patients presenting with myocardial infarction. In addition, it is not known if correction of hyponatremia impacts outcomes in these patients. The aim of this study was to evaluate the prognostic value of hyponatremia in patients with myocardial infarction and the effect of its correction on all-cause mortality.
methodsPatients with the discharge diagnosis of myocardial infarction at our institution between 2000 and 2010 with serum sodium levels measured within 24 h of admission were included in this retrospective analysis. Multivariate analysis was used to determine the predictors of all-cause mortality. Cox proportional hazard model was applied to determine the adjusted survival.
resultsA total of 11,562 patients (67.15 ± 14.6 years, males 56.3 %) were included in the analysis. There were a total of 1,535 (13.3 %) deaths within mean follow-up duration of 5.5 ± 3.3 years. There were 425 (27.9 %) deaths in patients with corrected hyponatremia and 155 (55.3 %) deaths in persistent hyponatremia patients. Multivariate analysis indicated that corrected hyponatremia and persistent hyponatremia were independent predictors of all cause mortality (p < 0.0001). When analyzing short-term (30 days) and long-term mortality, corrected hyponatremia group did not have associated long term mortality. Various methods to correct hyponatremia were also analyzed and use of vaptans was associated with decrease in mortality in patients with hyponatremia from 115 to 125 (HR 0.45; 95 % CI 0.26-0.78, p = 0.005).
conclusionOur analysis showed that corrected and persistent hyponatremia in patients presenting with myocardial infarction is a predictor of all-cause mortality, major adverse cardiac events and heart failure related 30 day rehospitalization. In certain cases, correction of hyponatremia may actually improve survival of the patients.
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