ReviewJournal of neural transmission (Vienna, Austria : 1996)2013
The impairment of lysyl oxidase in keratoconus and in keratoconus-associated disorders.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The Association Between Keratoconus and Mitral Valve Prolapse: A Meta-Analysis.Current cardiology reviews · 2020Pooled it
- Imbalance of Pro-Oxidant and Anti-Oxidant Biomarkers in Patients with Keratoconus.Antioxidants (Basel, Switzerland) · 2026Article
- PI3K signaling and lysyl oxidase is critical to corneal stroma fibrosis following mustard gas injury.Experimental eye research · 2025Article
- Article
- Keratoconus.Nature reviews. Disease primers · 2024Article
- Genetic variants in the FOXO1 and ZNF469 genes are associated with keratoconus in Sweden: a case-control study.BMC ophthalmology · 2024Article
- Systemic Associations with Keratoconus.Life (Basel, Switzerland) · 2023Review
- Keratoconus Diagnosis and Treatment: Recent Advances and Future Directions.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Elastin turnover in ocular diseases: A special focus on age-related macular degeneration.Experimental eye research · 2022Review
- Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy.International journal of molecular sciences · 2022Review
- Pediatric keratoconus - Current perspectives and clinical challenges.Indian journal of ophthalmology · 2021Review
- Risk of Mitral Valve Prolapse in Patients with Keratoconus in Taiwan: A Population-Based Cohort Study.International journal of environmental research and public health · 2020Article
- Three novel variants identified within ECM-related genes in Chinese Han keratoconus patients.Scientific reports · 2020Article
- A comparative study of the elastic fibre system within the mouse and human cornea.Experimental eye research · 2018Article
- [Gene expression of down-regulation of lysyl oxidases family in keratoconus corneal fibroblasts induced by combination of mechanical stretching and prostaglandin ESheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017Article
- Keratoconus: an inflammatory disorder?Eye (London, England) · 2015Review
- Impaired corneal biomechanical properties and the prevalence of keratoconus in mitral valve prolapse.Journal of ophthalmology · 2014Article
- Screening for NovelJournal of ophthalmic & vision researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratoconus (KC) is an eye disease characterized by the progressive thinning and protrusion of the cornea, which results in the loss of visual acuity. This disorder remains poorly understood, although recent studies indicate the involvement of genetic and environmental factors. Recently, we have found that the distribution of the cross-linking enzyme lysyl oxidase (LOX) is markedly decreased in about 63 % of keratoconic specimens. Similarly, LOX activity is significantly reduced by 38 % compared to control tissue. Nearly 70 systemic disorders have been reported in association with KC, most of them affecting the extracellular matrix. In this review we attempted to ascertain whether any KC-associated diseases exhibit signs that may reflect LOX impairment. We hypothesized that very similar changes in the extracellular matrix, particularly at the level of collagen metabolism, including LOX impairment in mitral leaflets, may reflect an association between KC and mitral valve prolapse. Moreover, this putative association is supported by the high frequency of Down syndrome in both diseases. Among other disorders that have been found to coincide with KC, we did not find any in which the LOX enzyme may be directly or indirectly impaired. On the other hand, in cases where KC is present along with other connective tissue disorders (Marfan syndrome, Ehlers-Danlos syndrome and others), KC may not arise as a localized manifestation, but rather may be induced as the result of a more complex connective tissue disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.