ArticleMicrobial ecology2013
Detection of methicillin-susceptible Staphylococcus aureus ST398 and ST133 strains in gut microbiota of healthy humans in Spain.
Article in Microbial ecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization ofFoods (Basel, Switzerland) · 2023Article
- Molecular Characterization of Methicillin-SensitivePathogens (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance and Antimicrobial Activity ofMicroorganisms · 2022Article
- Shared antibiotic resistance and virulence genes in Staphylococcus aureus from diverse animal hosts.Scientific reports · 2022Article
- Genetic characterization of livestock-associated methicillin-resistant Staphylococcus aureus isolated in Greece.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Multi-species host range of staphylococcal phages isolated from wastewater.Nature communications · 2021Article
- Human Infection of Methicillin-SusceptibleMicroorganisms · 2020Review
- Prevalence, Characterization, and Drug Resistance ofFrontiers in medicine · 2020Article
- CC398 Staphylococcus aureus subpopulations in Belgian patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Prevalence and molecular characterization ofAntimicrobial resistance and infection control · 2018Article
- Genetic Diversity and Virulence Potential of Staphylococcus aureus Isolated from Crayfish (Procambarus clarkii).Current microbiology · 2017Article
- Fecal Carriage of Staphylococcus aureus in the Hospital and Community Setting: A Systematic Review.Frontiers in microbiology · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fecal samples of 100 healthy humans were tested for Staphylococcus aureus recovery. Fifteen samples (15 %) contained S. aureus, all methicillin-susceptible (MSSA), being one isolate/sample further studied. These 15 isolates were characterized by spa and agr typing as well as multi-locus sequence typing. High diversity of spa types (n = 11) and sequences types (n = 8) was detected. Two S. aureus of lineages ST398 or ST133 were detected, and six isolates were ascribed to clonal complex 30 (CC30). Strains were susceptible to most of the 17 antimicrobial agents tested with exceptions: erythromycin/clindamycin (three strains, containing erm(C) and/or erm(A) + mph(C) genes) and tobramycin and mupirocin (one strain containing ant(4')-Ia + mup(A) genes). The presence of 18 staphylococcal enterotoxin genes was studied by PCR, and isolates were negative for lukF/lukS-PV genes, although strain ST133 harbored the lukD-lukE + lukM genes. Other virulence genes detected were (number of strains): tsst-1 (6), hla (15), hlb (9), hld (15), hlg (6), hlgv (9), cna (2), aur (14), and egc-like cluster (3). Analysis of immune evasion cluster genes showed six types, highlighting their absence in two strains of lineages ST133 and ST5. A high clonal diversity of MSSA strains was identified in the intestinal microbiota of healthy humans, being CC30 the most frequent one. This is the first report of MSSA ST133 and ST398 isolates in gut microbiota of healthy humans.
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