ArticleMolecular biology reports2013
The cloning of the cdk2 transcript and the localization of its expression during gametogenesis in the freshwater giant prawn, Macrobrachium rosenbergii.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 20 citations in OpenAlex.
- Involvement of the ovarian-specific Mro-IR in oogonia differentiation and oocyte development in freshwater giant prawnFrontiers in endocrinology · 2025Article
- Transcriptome analysis of reproductive tract tissues of male river prawn Macrobrachium americanum.Molecular biology reports · 2024Article
- Comparative Transcriptome Reveals the Potential Modulation Mechanisms of Spfoxl-2 Affecting Ovarian Development of Scylla paramamosain.Marine biotechnology (New York, N.Y.) · 2022Article
- Full Functional Sex Reversal Achieved Through Silencing ofFrontiers in endocrinology · 2021Article
- Identification and Characterization of a Luteinizing Hormone Receptor (LHR) Homolog from the Chinese Mitten CrabInternational journal of molecular sciences · 2019Article
- Identification and profiling of microRNAs during gonadal development in the giant freshwater prawn Macrobrachium rosenbergii.Scientific reports · 2019Article
- Characterization, expression and silencing by RNAi of p53 from Penaeus monodon.Molecular biology reports · 2016Article
- Transcriptome analysis of red swamp crawfish Procambarus clarkii reveals genes involved in gonadal development.PloS one · 2014Article
- Molecular cloning, characterization and expression analysis of a novel PDRG1 gene from black tiger shrimp (Penaeus monodon).Genetics and molecular biologyArticle
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5 authors at 1 institution in 1 country.
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Abstract
Cyclin-dependent kinases (cdks) are key regulators of the cell cycle. In mammals, cdk2 plays an essential role in the meiosis of spermatocytes and oocytes. To investigate the role of cdk2 kinase during gametogenesis in crustaceans, we cloned a complete cDNA sequence of cdk2 from the freshwater giant prawn, Macrobrachium rosenbergii, and examined its localization and expression in the developing gonads. The prawn cdk2 cDNA is 1,745 bp in length and encodes a putative protein of 305 amino acids. The deduced protein contains a conserved cyclin binding motif PSTAIRE and shares high homology with reported cdk2 kinases of other species. RT-PCR analysis showed a wide distribution of the cdk2 mRNA in all tested organs including the testis, ovary, heart, muscles, hepatopancreas and gills, and the highest level of expression in the ovary and testis. Localization by in situ hybridization of cdk2 mRNA in the ovary showed high expression in the ooplasm of previtellogenic and the nuclei of late vitellogenic oocytes. In testicular sections, cdk2 transcript is low in spermatogonia, high in spermatocytes, but reduced in spermatids and sperm. The high expression of the cdk2 transcripts in meiotic spermatocytes and oocytes indicated that the cdk2 gene has the conservative function in the germ cells meiosis during gametogenesis.
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